Personalized TCR-T Team Lead

Title: Personalized TCR-T Team Lead

Location: Upper East Side

Org Unit: MCC Laboratories

Work Days:

Weekly Hours: 35.00

Exemption Status: Exempt

Salary Range: $165,700.00 - $188,000.00

*As required under NYC Human Rights Law Int 1208-2018 - Salary range for this role when Hired for NYC Offices
Position Summary

Responsible for establishing and driving a cutting-edge research group and platform for personalized TCR-based cell therapies targeting autologous tumors. The mission of this team is to build a rigorous, high-throughput discovery and preclinical development engine that identifies high throughput and with high confidence tumor-specific TCRs for downstream analysis, engineering, and translational development. The Lead integrates immunologic insight, genomic analysis, and clinical collaboration to advance personalized TCR gene therapy for patients.


Job Responsibilities

• Design and implement an end-to-end personalized TCR discovery workflow including tumor-reactive T cell identification, TCR cloning, specificity validation, and safety de-risking leading to the selection of personalized TCRs for clinical application
• Develop platform of experimental massive parallel screening of T cells for recognition of autologous tumor cell lines or tumor antigen-expressing APCs; purification and analysis of tumor-reactive T cells.
• Develop workflow for human T cell isolation, scRNA/TCRseq and computational inference of tumor-reactive T cells. Understand deeply relevant computational methods and work closely with computational experts.
• Establish platform for massive parallel TCR cloning and screening; deep TCR characterization including affinity, avidity and functionality in a cellular context.
• Directly analyze and interpret complex patient-based campaigns for identification of TCRs. Integrate data across functional potency, specificity, and safety to support go/no-go decisions on specific TCRs.
• Establish and optimize advanced de-risking methods and workflows to assess alloreactivity, unintended HLA interactions, off-target toxicity risk including X-scan, peptide library screens and library-on-library HTS.
• Develop a platform of cell-based systems and in vitro surrogates of normal tissues to assess TCR risk.
• Contribute to translational packages (reports, assay descriptions, validation summaries) supporting IND/CTA-enabling preclinical data.
• Collaborate with cross functional teams to integrate learnings and advance gene therapy initiatives.

Education

• Master's Degree or Ph.D. in an appropriate field. Equivalent work experience will be considered.

Experience

A minimum of 10 years of post-PhD experience in TCR discovery, ideally applied to cell therapy development.

Approximately 3 years or related experience in GLP/GMP or Pharmaceutical environments.

Experience in working closely with computational teams, interpreting high-dimensional datasets, and integrating quantitative outputs into experimental design.

Passion for bridging rigorous basic science with translational impact; resilient, innovative, and comfortable in a fast-paced, milestone-oriented environment.

Proven track record leading small-to-medium teams on complex, multi-stakeholder translational projects or platform builds, ideally in a translational or biotech-like setting, with demonstrated ability to advance candidates from discovery to preclinical validation.

Knowledge, Skills and Abilities

• Deep technical expertise in high-throughput TCR screening, single cell technologies and TCR repertoire analysis, TCR cloning/expression, functional validation, and safety de-risking.
• Ability to build scalable and reproduceable identification pipelines for personalized TCR therapy programs.
• Familiarity with institutional and federal regulatory documentation and compliance standards.
• Excellent communication skills in English, with the ability to interact effectively with clinicians, basic scientists, and operational stakeholders.
• Effective communication skills to translate complex discovery findings into actionable development decisions.

Licenses and Certifications

Working Conditions/Physical Demands

Ability to work flexible hours, evenings and weekends, when requested for special projects.

Cornell welcomes students, faculty, and staff with diverse backgrounds from across the globe to pursue world-class education and career opportunities, to further the founding principle of 'any person, any study.' No person shall be denied employment on the basis of any legally protected status or subjected to prohibited discrimination involving, but not limited to, such factors as race, ethnic or national origin, citizenship and immigration status, color, sex, pregnancy or pregnancy-related conditions, age, creed, religion, actual or perceived disability (including persons associated with such a person), arrest and/or conviction record, military or veteran status, sexual orientation, gender expression and/or identity, an individual's genetic information, domestic violence victim status, familial status, marital status, or any other characteristic protected by applicable federal, state, or local law.

Cornell University embraces diversity in its workforce and seeks job candidates who will contribute to a climate that supports students, faculty, and staff of all identities and backgrounds. We hire based on merit, and encourage people from historically underrepresented and/or marginalized identities to apply. Consistent with federal law, Cornell engages in affirmative action in employment for qualified protected veterans as defined in the Vietnam Era Veterans' Readjustment Assistance Act (VEVRRA) and qualified individuals with disabilities under Section 503 of the Rehabilitation Act. We also recognize a lawful preference in employment practices for Native Americans living on or near Indian reservations in accordance with applicable law.



To apply, visit https://jobs.weill.cornell.edu/NY/job/New-York-Personalized-TCR-T-Team-Lead-NY-10021/1391026400/







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