We are looking to recruit a highly motivated Postdoctoral Associate for our newly initiated research program centered around compartmentalized G protein signaling by internalized G protein-coupled receptors (GPCRs) in the Thomsen Laboratory of Biomolecular Pharmacology at New York University. Over the past years, we discovered a new signaling paradigm whereby certain GPCRs can stimulate G protein signaling from endosomes through the formation of a unique receptor complex termed the "megaplex" (Thomsen, Plouffe, Cahill III et al. (2016), Cell; Cahill III & Thomsen et al. (2017), PNAS; Nguyen, Thomsen, Cahill III et al. (2019), Nat Struct Mol Biol). As we now understand this mechanism to the near-atomic level, our current research focus is to study how the megaplex regulates physiological functions. In this regard, we are particularly interested in how compartmentalized signaling of the vasopressin type 2 receptor (V2R) regulates water reabsorption.  

The primary project of the successful candidate funded by the NIGMS aims to develop a deep understanding of cellular processes taking place during water reabsorption in the renal collecting duct. In recent years, we have completed several studies that focused on signaling aspects of the V2R, and therefore, we now want to tie those finding to physiological outcomes. The project will involve characterization of disease-associated V2R mutants, how compartmentalized V2R signaling regulate aquaporin biology, and the development of renal collecting duct models. The primary experimental approaches to be used for this project include cell & molecular biology, advanced microscopy (super-resolution and/or electron microscopy), and cell-based assays.

As we are dedicated to utilizing the insights learned from this project to the design of innovative therapeutic solutions, this position is ideal for individuals who are committed to a research career in academia or in bioentrepreneurship.

In addition, it is also expected that the applicant will participate in related secondary projects and collaborative projects within and/or outside our laboratory. Finally, this position also involves supervision and training of undergraduate/graduate students.

In compliance with NYC?s Pay Transparency Act, the annual base salary range for this position is $52,500-62,500. New York University considers factors such as (but not limited to) the specific grant funding and the terms of the research grant when extending an offer.

We are searching for candidates with a Ph.D. and/or M.D. degree and a strong background in cell & molecular biology.  Prior knowledge of GPCR biology is much preferred but not essential. We are looking for motivated and creative individuals who can work independently while maintaining a team-based mindset. Strong ability to problem solve and troubleshoot experiments is essential. Outstanding oral and written communication skills are required.

Minimum Qualifications:

Ph.D. and/or M.D. in Biomedical Research required.

Please submit a resume/CV and at least three reference letters addressed to Dr. Alex Thomsen, PhD, Assistant Professor, NYU Pain Research Center, Department of Molecular Pathobiology, New York University College of Dentistry, 433 1^st Avenue Room #706, New York, NY 10010.

For more information about the laboratory, please visit: www.thomsen-lab.com

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