Ann Arbor, Michigan
Charlotte, North Carolina
Berkeley, California
Boston, Massachusetts
Los Angeles, California
Oakland, California
Lexington, Virginia
Cincinnati, Ohio
Posted: 03-Feb-26
Type: Full-time
Categories:
Internal Number: R144117
Position Overview: The Visiting Scholar will conduct independent research under the guidance of a scientific mentor in the areas of ovarian and endometrial cancer biology, with a primary focus on extracellular vesicle (EV)mediated mechanisms of tumorigenesis. This research aims to elucidate how EV-associated proteins contribute to cancer initiation and progression, providing critical insights for the development of novel preventive strategies, biomarkers, and targeted therapies.
Growing evidence indicates that secretory epithelial cells of the distal fallopian tube (FTSECs) serve as the cell of origin for the majority of high-grade serous ovarian cancers (HGSOC). In parallel, members of the transmembrane (TMEM) protein family have emerged as oncogenic drivers in multiple cancers. This project will investigate whether TMEM205 promotes FTSEC and HGSOC cell proliferation by enhancing exosome secretion and altering exosomal protein cargo, and whether TMEM205 contributes to HGSOC progression through downregulation of PIAS3.
Additionally, this research seeks to identify exosomal protein signatures unique to ovarian and endometrial cancers, with the potential to serve as clinically actionable biomarkers. The work offers strong bench-to-bedside translational relevance, providing the Visiting Scholar with opportunities to engage in clinical and translational research, particularly in ovarian and endometrial cancer.
Experience Requirements
Doctoral degree (PhD or MD) in Biomedical Sciences, OB/GYN, or a related field, 12 years of research experience in cancer biology or a closely related area Demonstrated ability to conduct independent, productive research, as evidenced by: Peer-reviewed publications, Conference presentations. Contributions to novel methods, experimental designs, or translational applications relevant to ongoing research programs
