Research Associate â“ Ramani Lab, Gladstone Institutes

Who We Are
The Gladstone Institutes is a leading independent, not-for-profit research organization dedicated to improving human health through groundbreaking biomedical research and education. Our work spans neuroscience, cardiovascular biology, immunology, and stem cell biology, with a strong emphasis on understanding and treating disease. With approximately 600 team members, including world-renowned scientists and biomedical leaders, Gladstone fosters a collaborative and innovative environment. Located at the Mission Bay Campus in a state-of-the-art facility, we offer competitive salaries, comprehensive benefits, and the resources to empower individuals to maximize their potential and make a meaningful impact on global health.

About the Role
The Ramani Lab at Gladstone Institutes is seeking a highly motivated Research Associate to support wet-lab research initiatives. The Ramani Lab specializes in the development and application of cutting-edge sequencing technologies to investigate transcriptional regulation at a genome-wide scale. Our work encompasses methodologies for analyzing chromosome structure, accessibility, and transcriptional programs across diverse cell types and extracellular conditions.

The Research Associate will be responsible for generating single-cell and single-molecule sequencing libraries compatible with Illumina and PacBio sequencing platforms, conducting a variety of molecular biology experiments, purifying proteins using bacterial, insect, and mammalian expression systems, and analyzing sequencing data. The ideal candidate will have a strong background in molecular biology, excellent organizational and communication skills, and the ability to work independently. Candidates willing to commit at least two years to the position will be preferred.

What you will do:

• Conduct molecular biology experiments to create sequencing libraries for high-throughput sequencing platforms.

• Develop and optimize molecular biology protocols, including barcoding, amplification, and processing of DNA and RNA from mammalian cells.

• Perform biochemical techniques such as protein purification and in vitro reconstitution of molecular processes.

• Assist with lab organization, including reagent procurement and inventory management.

• Collaborate with team members to analyze and interpret sequencing data.

What you will need:

• B.S./B.A. degree in a relevant scientific field by the time of hire.

• Prior experience in molecular biology laboratory techniques and/or protein purification and biochemistry.

• Candidates currently completing their degree may apply, but the degree must be conferred by the appointment start date.

What is preferred:

• Experience with high-throughput sequencing technologies, including Illumina, Pacific Biosciences, or Oxford Nanopore.

• Familiarity with mammalian tissue culture techniques.

• Proficiency in bioinformatics or scripting languages such as UNIX, C++, Python, or R.

About Gladstone Institutes

The Gladstone Institutes is an independent, not-for-profit research institution affiliated with the University of California San Francisco (UCSF), transforming the health and well-being of all people through medical research, education, and outreach in the fields focused on heart disease, immunology and virology including HIV/AIDS, and neurological disease. Home to notable leaders in the field of medical science, including 2012 Nobel Prize in Physiology or Medicine recipient Shinya Yamanaka, M.D.,Ph.D. Gladstone is comprised of four institutes in addition to various Centers and programs focusing approximately 500 members of our team on its mission: Science Overcoming Disease. Located in an award-winning building adjacent to UCSF's Mission Bay Campus, Gladstone offers a competitive salary and benefits program within a robust environment for those seeking to maximize their potential. Please consider Gladstone and make a difference in human health.

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