Summary:
We are excited to announce the launch of our new lab in January 2025, within the Department of Genetics, Cell Biology, and Development at the University of Minnesota. We are seeking a highly motivated postdoctoral associate to join our team. This role involves developing and applying single-cell systems biology approaches to elucidate how signaling variability at the single-cell level contributes to cancer progression and to tackle challenges in cancer treatments.

About Our Lab:
Our lab uses mass cytometry to profile the states and dynamics of up to 40 intracellular phosphorylation sites on key signaling proteins in single cells. This comprehensive measurement enables us to precisely determine the signaling and physiological states of each individual cell, including growth, proliferation, and responses to stress and inflammation, and to understand how these signaling activities integrate to determine cell fate.

We also engineer dynamic and reactive DNA probes to expand the sensitivity and coverage of protein post-translational modification assessment and protein-protein interaction analysis. Combined with advanced single-cell and omics approaches, our methods allow for in-depth exploration of intracellular signaling networks and physical interaction networks in health and diseases.

Using these methods, we aim to comprehensively interrogate the heterogeneous intracellular signaling networks involved in cancer progression. We seek to identify intracellular signaling responses underlying diverse susceptibility to cancer treatments and specific kinase inhibitors in clinical settings, ultimately aiming to enhance outcomes for cancer patients through the discovery of new druggable targets.

Learn more about us at lun.umn.edu, or directly contact Dr. Xiaokang Lun (xlun@umn.edu).

Responsibilities:   

⢠Mass cytometry analysis with the state-of-the-art CyTOF XT system
⢠Development and validation of novel single-cell methodologies and protocols
⢠Experiments with cultured mammalian cell lines, primary cells, and patient-derived human cell samples
⢠Single-cell data analysis with advanced computational approaches
⢠Writing and publishing research findings in scientific journals
⢠Participating in lab meetings and journal clubs
⢠Supervising trainees and students in the laboratory


Application Process:

Interested candidates should submit the following documents:

⢠A cover letter describing your research interests and career goals
⢠A detailed CV including a list of publications
 

Required Qualifications:  

⢠Ph.D. or MD/Ph.D. degree in systems biology, molecular biology, biochemistry, cancer biology, immunology, pharmacology, or related fields

Preferred Qualifications:

⢠Expertise or experience with mass cytometry, single-cell sequencing, or mass spectrometry
⢠Computational skills with Python, R, or MATLAB
⢠Good publication record
⢠Excellent verbal and written scientific communication skills
 

About University of Minnesota Twin Cities

The University of Minnesota, founded in the belief that all people are enriched by understanding, is dedicated to the advancement of learning and the search for truth; to the sharing of this knowledge through education for a diverse community; and to the application of this knowledge to benefit the people of the state, the nation, and the world.

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