• Job Type: Support Staff - Union
• Bargaining Unit: SSA
• Regular/Temporary: Regular
• End Date if Temporary:
• Hours Per Week: 35.00
• Standard Work Schedule:
• Building:
• Salary Range: 59,845.49 - 59,845.49

Position Summary

We are seeking a full-time Senior Technician to join Dr. Neil Shneider? s lab in the Motor Neuron Center at Columbia University Irving Medical Center in New York, NY. The Senior Technician will join an ongoing research effort using novel mouse models of ALS/FTD and human tissue samples to explore molecular and cellular mechanisms underlying neurodegeneration in ALS, frontotemporal dementia (FTD) and related disorders.

Responsibilities

The Senior Technician will:

• Carry out basic histological preparations of human and mouse tissues using existing protocols or developing and optimizing additional immunohistochemical methods as necessary
• Analyze stained tissues using advanced imaging techniques, including confocal microscopy
• Perform molecular biology and biochemical experiments, such as western blotting, electrophoresis, RNA/DNA/Protein isolations, and PCR
• Develop and maintain IACUC protocols while also managing the laboratory?s mouse colony through husbandry, genotyping and a range of molecular, cellular and behavioral assays to be characterize different mouse lines
• Maintain laboratory equipment and records, perform quality control and quality assurance activities as needed.
• Perform miscellaneous functions required to maintain operation of the laboratory such as liaising with the university EH&S office, ensuring the lab is compliant with state, local and university rules and regulations and ordering reagents for lab work.

Minimum Qualifications

• Requires a bachelor's degree and at least 1.5 years of related experience or equivalent in education, training and experience. 

Preferred Qualifications

• A bachelor's degree in chemistry, biology, physics, or related science preferred. 
• A working knowledge of experimental methods in cellular and molecular neurobiology.
• Comfort around human-derived tissues/samples.
• Experience in RNA sequencing and computational methods is an advantage but not required.
• Prior experience working with mouse models of disease is preferred.  
• Demonstrated organizational skills and a strong attention to detail
• Proficiency in Excel and use of Internet resources for literature searches and database mining.

Equal Opportunity Employer / Disability / Veteran

Columbia University is committed to the hiring of qualified local residents.

About Columbia University

Columbia University is one of the world's most important centers of research and at the same time a distinctive and distinguished learning environment for undergraduates and graduate students in many scholarly and professional fields. The University recognizes the importance of its location in New York City and seeks to link its research and teaching to the vast resources of a great metropolis. It seeks to attract a diverse and international faculty and student body, to support research and teaching on global issues, and to create academic relationships with many countries and regions. It expects all areas of the university to advance knowledge and learning at the highest level and to convey the products of its efforts to the world.

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