GENERAL SUMMARY/ OVERVIEW STATEMENT:

We are a vibrant group applying biological, physiological and computational tools to understand and identify new treatments for motor and sensory neuron diseases. The laboratory is seeking a motivated and enthusiastic research assistant with experience in molecular biology and in particular stem cell biology to support preclinical studies related to Amyotrophic Lateral Sclerosis (Lou Gehrig's Disease) and pain. The research technician will contribute to the intellectual development of a project, attend and present at lab meetings, and engage in the scientific community through opportunities to attend conferences and publish papers. The major responsibilities will include stem cell culture and differentiation, analysis of molecular disease-related phenotypes using patient and control as well as gene-edited iPSC lines, quantitative analysis of expression and sequence data, general molecular biology techniques such as immunohistochemistry, RNA isolation and PCR to analyze the cells of interest. Additional work will include assistance with ordering, laboratory maintenance and animal husbandry. Preference will be given to individuals who are able to make a 2-year commitment to the role.

PRINCIPAL DUTIES AND RESPONSIBILITIES:

Will be responsible for the following:

• Stem cell culture and differentiation
• High-content imaging and physiology (calcium imaging/ optogenetics)
• Bioinformatic analysis of expression and sequence data
• Mouse brain and spinal cord dissection
• Purification of RNA and PCR
• Perform task associated with ordering, animal husbandry, and lab uptake
• Assist with training other personnel as appropriate
• Accurate maintenance of records of laboratory work in sufficient detail for reproduction of the experiments, organizing, analyzing and summarizing acquired data.
• May assist with drafting or contributing to the preparation of research papers, manuscripts or other documents for publication and/or presentation.

SKILLS/ABILITIES/COMPETENCIES REQUIRED:

• Must be an enthusiastic, diligent and professional team player with excellent time management skills.
• Meticulous detail about laboratory techniques and documentation are required, as are the ability to work independently and as a member of a team.
• Must possess excellent verbal and written communication skills.
• Computer literacy

The Research Technician II should also possess:

• Analytical skills and the ability to resolve technical problems
• Ability to interpret acceptability of data results
• Working knowledge of data management programs
• Demonstrated competence in research techniques and methodologies

Qualifications
EDUCATION:

• Bachelor's degree required.

EXPERIENCE:

• New graduates with some lab experience (via course work, internships, etc.) or those without any prior research experience will be considered for the Research Technician I position outlined above.
• Those with a minimum of 1 year of directly related work experience will be considered for a Research Technician II position.

SUPERVISORY RESPONSIBILITY (if applicable):

• A Research Technician II may serve as a team leader to lab assistants and Research Technician I's.

EEO Statement
Massachusetts General Hospital is an Equal Opportunity Employer. By embracing diverse skills, perspectives and ideas, we choose to lead. Applications from protected veterans and individuals with disabilities are strongly encouraged.Partner's Healthcare is acting as an Employment Agency in relation to this vacancy.

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