Herc-Higher Education Recruitment Consortium

There is a position open for a Researcher Scientist 5 available immediately in the Masonic Cancer Center, University of Minnesota.  The lab is interested in understanding the contribution of insulin and insulin-like growth factor (IGF) action in breast cancer.  We have shown that IGF-I can stimulate cell growth, enhance survival, and stimulate motility and adhesion.  Activation of specific substrates, insulin receptor substrate-1 (IRS-1) and IRS-2 are associated with either cell proliferation or cell motility. We have also shown that the fetal form of the insulin receptor (IR-A) also is expressed at high levels in breast cancers. Projects in the laboratory include identifying key signaling pathways downstream of the insulin and type I IGF receptor, evaluating potential anti-IGF and IR-A therapies, and evaluating the role of hyperinsulinemia in animal model systems of breast cancer. Our long-term goal is to improve breast cancer treatment by understanding and targeting the key components of the IGF/insulin system.

Duties:

• Design, prepare, carry out, analyze, present and report of research data
• Conduct xenograft studies using athymic mice
• Train and supervise junior lab members and students (undergrad, grad, rotation, summer)
• Provide assistance with trouble shooting of lab research projects
• Author, co-author, and otherwise collaborate on reports, conference papers, and publications.
• Place orders and receiving for lab purchases
• Train and orient new and current lab members in addition to safety officer for the lab

All required qualifications must be documented on application materials. 

Required Qualifications:

• Advanced degree in cell biology or a related field or a minimum of 5 years of experience

Preferred Qualifications:

• Ability to work independently as well as with a diverse group of people
• Ability to develop and adapt scientific protocols to ensure high quality reproducible data are obtained
• Required skills include tissue culture, western blotting, proliferation assays, migration assays, RT-PCR, flow cytometry, anchorage independent assays and protein production. 
• Experience with mouse handling