Cancer Early Detection Advanced Research (CEDAR) center is a collaborative institution within the OHSU Knight Cancer Institute. The Knight Cancer Institute, known as one of the pioneers in personalized cancer medicine, is an international leader in research and cancer treatment. At CEDAR our mission is to detect and stop lethal cancers at the earliest stage because early detection saves lives. This is an ambitious goal, one that requires novelty, creativity, and innovation. We are composed of biologists, chemists, biomedical engineers, computationalists, and clinicians conducting groundbreaking translational cancer research to help people maintain a high quality of life and reduce cancer mortality, to create a global early detection community, and to have a positive impact on the Oregon economy.
CEDAR is committed to increasing the diversity of the campus community. We at CEDAR are dedicated to promoting inclusion and multiculturalism to build a successful organization by having outstanding researchers of diverse backgrounds work together on multiple projects. We encourage high-risk, high-reward research projects because defeating cancer requires unproven, out-of-the-box thinking. Our research is milestone driven to ensure that each project is fulfilling its stated goals.
Every Knight Cancer employee is expected to embody our guiding principles:
We act BOLDLYBreakthroughs require pushing the boundaries of science, exploring new frontiers, and thinking differently
We SUPPORT each otherRespect leads to trust, which leads to excellenc
We work as a CONNECTED teamWe must leverage our collective brain power to conquer cancer because no one individual can do it alone
As a Senior Research Assistant , you will be part of collaborative project teams focusing on advancing early cancer detection. Under close supervision, you will be trained by an experienced team and support CEDAR research by contributing to projects using mass spectrometry. You will work as part of the proteomic team to benchmark instrument performance, process raw mass spectrometry data, perform exploratory data analysis, data wrangling, and assist with data management and organization. Prior experience and background in bioinformatics, statistics, and R are required. Additional experience in mass spectrometry and/or proteomic data processing and analysis are a bonus, but not required for the position.
Proteomic Data Processing
Perform initial processing of raw mass spectrometry (MS) datasets using multiple proteomics software tools including MSFragger, MaxQuant, Spectronaut, and DIA-NN using established protocols
Log and generate graphical displays to benchmark performance metrics for QC samples in order to monitor instrument performance over time using tools such as Skyline/Panorama
Proteomic Data Organization and Management
Facilitate transfer of raw mass spectrometry data files from acquisition systems to processing platforms
Dynamically update logs for MS analysis runs performed, detailing critical parameters such as injections amounts, analytic columns and trap types, gradients lengths, data acquisition method employed etc
Manage organization and backup of both raw mass spectrometry data files, resulting output data from proteomic searches, and downstream analysis files in cloud-based storage systems
Proteomic Data Analysis
Perform basic data cleaning, annotation, consolidation, and analysis on searched output data using either GUI-based proteomics software such as Perseus or in R
Expand proteomic dataset analytic repertoire over time to include more sophisticated analysis of raw proteomic MS datasets, leveraging mentoring from internal and external proteomics data experts
General CEDAR support
Serve as secondary (back-up) support for overall CEDAR lab function by maintaining and fixing equipment, ordering supplies, organizing, record keeping, or troubleshooting
Additional duties as assigned by project leader or laboratory manager
Bachelors Degree (4 yr) with major courses in field of research and 1 to 3 years of relevant experience
Experience managing and processing research data/files
Data wrangling, exploratory analysis, and statistical analysis
Proficiency in R/R-Studio
Ability to effectively convey and summarize work through written reports and visualizations
Ability to work independently and as part of a team while being collaborative in resolving problems
Ability to prioritize multiple tasks at one time
Ability to learn new and innovative processes quickly
Ability to use tact and diplomacy to maintain effective working relationships
Bachelors Degree (4 yr) with major courses in bioinformatics, computer, science, and/or statistics
Masters Degree with major courses in relevant disciplines such as bioinformatics, computer, science, and statistics and 0-2 years of experience
Experience working with mass spectrometry-based proteomic data
Knowledge in MS proteomic data processing tools such as MaxQuant, MSFragger, DIA-NN, Spectronaut, or Skyline
Apply online. Please be sure to upload a Cover Letter and Resume/CV.
Oregon Health & Science University values a diverse and culturally competent workforce. We are proud of our commitment to being an equal opportunity, affirmative action organization that does not discriminate against applicants on the basis of any protected class status, including disability status and protected veteran status. Individuals with diverse backgrounds and those who promote diversity and a culture of inclusion are encouraged to apply. To request reasonable accommodation contact the Affirmative Action and Equal Opportunity Department at 503-494-5148 or email@example.com.
As the state's only health and research university, OHSU brings together patient care, research, education of the next generation of health care providers and scientists and community service to improve the health and well-being of all Oregonians.The university is a conduit for learning for more than 2,800 students, providing training to interns, residents and fellows in postgraduate medical and research. It is the only place in Oregon that grants doctoral degrees in medicine, dentistry and nursing. OHSU cares for more than 251,000 patients each year from around the region and takes a leadership role in contributing to solutions involving the health of the state and the nation, such as health care access and transparency, ethics and workforce shortage. Beyond providing critical health care services, quality education and cutting-edge research, OHSU also is a key economic and social force in the Northwest. With an annual operating budget of $2.06 billion and more than 14,000 employees, OHSU is Portland?s largest employer. Its size contributes to its ability to provide... many services and community support activities not found anywhere else in Oregon. For more information visit http://www.ohsu.edu/xd/about/index.cfm