The University of Southern California, School of Pharmacy is seeking an experienced research scientist for an immediate opening as Associate Director of the Medicinal Chemistry Core Facility.
The successful candidate will be a highly motivated scientist with a proven track record of delivering innovative assets in drug discovery to support basic, translational and clinical research in the biomedical enterprise at USC. The individual will be responsible for establishing and overseeing a core facility that provides a comprehensive suite of capabilities for preclinical drug discovery, complete with experienced project management. Core Services will include: 1) Structure-based lead identification and optimization; 2) Computational modeling of drug targets, protein-drug and protein-protein interactions and prediction of drug absorption, distribution, metabolism, excretion and toxicity; 3) Quantitative structure activity and structure-toxicity relationship analyses; 4) Chemical synthesis; 5) Analytical services; and 6) Support of grant applications for available funding mechanisms. The individual is expected to employ a collaborative approach to work closely with the USC research community and with external partners on all aspects of their projects, including: consultation and practical interpretation of datasets, effectively communicating project progress, writing technical summaries, and assisting as needed with publications and grant applications.Â Additional responsibilities include preparation and submission of instrumentation grants in support of the core facility, supervising and training facility staff, managing operating costs, ensuring a balanced budget and maintaining/troubleshooting equipment.
Education: A PhD in a scientific discipline is required for this position, preferably in Synthetic Organic Chemistry, Medicinal Chemistry, Biochemistry, or related field.
Experience: At least 5 years of medicinal chemistry experience, with preferably at least three years experience in a core facility or industry.
Strong proficiency in fundamental aspects of drug discovery and demonstrated ability to advance drug discovery programs are required.
Strong working knowledge of protein-ligand interactions, conformational and structural analysis, experienced in partnering closely with interdisciplinary scientists.
Extensive knowledge of synthetic organic chemistry and superior problem-solving skills; experience in designing and executing multistep synthesis of complex organic molecules.
Experience using modern techniques in organic chemistry. Solid understanding and application of pharmacology, PK/PD, and ADME concepts.
Knowledge and direct application of structure-based drug design computational tools to drive projects forward.
Exceptional oral communication and writing skills.
Enthusiastic, high energy, and collaborative individual with strong ability to build productive relationships with members of the USC research community and external partners.
Minimum Education: Bachelor's degreeMinimum Experience: 7 yearsMinimum Field of Expertise: Specialized, progressively responsible experience in laboratory instrumentation
USC is the leading private research university in Los Angeles—a global center for arts, technology and international business. With more than 47,500 students, we are located primarily in Los Angeles but also in various US and global satellite locations. As the largest private employer in Los Angeles, responsible for $8 billion annually in economic activity in the region, we offer the opportunity to work in a dynamic and diverse environment, in careers that span a broad spectrum of talents and skills across a variety of academic and professional schools and administrative units. As a USC employee and member of the Trojan Family—the faculty, staff, students, and alumni who make USC a great place to work—you will enjoy excellent benefits, including a variety of well-being programs designed to help individuals achieve work-life balance.