Research - Laboratory/Non-Laboratory, Staff/Administrative
The Al-Sady and El-Samad labs at UCSF have a Staff Research Associate I (SRA I) opportunity. Broadly, our labs at the intersection of synthetic and systems biology and chromatin biology. In this project, we are examining whether we can harvest epigenetic regulator parts from across evolution to craft synthetic gene regulatory circuits with novel behaviors. Specifically, we will use fission yeast as a testbed. The candidate will work under direct supervision of Dr. Al-Sady or a postdoctoral fellow to obtain chromatin regulator homologs from diverse phyla and species and replace the endogenous fission yeast regulators. The candidate will produce gene regulatory sensor strains with the modifiers and preliminarily characterize their behaviors. The candidate will have access to both the Al-Sady and El-Samad labs but be primarily housed in the Al-Sady lab at Parnassus Heights.
This job focuses more on the molecular biology of chromatin modifiers rather than biochemical purification and chromatin preparation. The phase of the project on chromatin biochemistry is now mostly complete and this is a continuation of the project which will require more cloning and yeast strain construction.
The candidate will order gene blocks for chromatin modifiers from across evolutionary phyla, clone them, and introduced them into our fission yeast sensor strains for heterochromatin assembly.
Internal Number: 3159516
About University of California, San Francisco
The University of California, San Francisco (UCSF) is a leading university dedicated to promoting health worldwide through advanced biomedical research, graduate-level education in the life sciences and health professions, and high-quality patient care. It is the only UC campus in the 10-campus system dedicated exclusively to the health sciences.