Research - Laboratory/Non-Laboratory, Staff/Administrative
The Staff Research Associate I, acting under direct supervision with training provided, will assist with several projects.
1. He/she will work to introduce viral vectors into adipocytes and hepatocytes, both primary and immortalized, in order to test the role of a particular secreted factor, angiopoietin-like 4, truncated versions of this protein, and potentially other angipoietin-like protein family members, on lipid uptake, metabolism, and secretion. Additional work will focus on pathways related to mitochondrial function and glucose homeostasis. Finally, the applicant will assist with studying mice with versions of angiopoietin-like 4 or family members expressed at high levels systemically.
2. He/she will work to test the role of ER stress and inflammatory pathway proteins, including ASK1, on myeloid cell and hepatocyte responses to lipid challenges that mimic the insults these cells face in the context of fatty liver disease.
3. He/she will work with human adipose tissue and myeloid cell samples to study the role of inflammation, fibrosis, and adipose remodeling in the development of insulin resistance in people across diverse ethnic groups.
4. He/she will help with molecular biology, protein biochemistry, lipid metabolism, and glucose metabolism-related projects being conducted by others in the lab.
Internal Number: 3148341
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