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The Department of Mechanical Engineering currently has an outstanding opportunity for a Full Time Temporary Research Scientist/Engineer I.
This position will support a research project with the goals of: (1) understanding the mechanisms by which cardiac myocytes sense mechanical stress and react by eliciting a compensatory hypertrophic response; (2) testing the therapeutic potential of overexpressing a candidate mechanosensitive gene in the context of cardiac regeneration therapy. Aim 2 of this project will be developed in close collaboration with the UW Heart Regeneration Program.
The job responsibilities for this position will include: (1) the generation and delivery of targeting constructs and CRISPR/Cas9 plasmids for gene editing experiments in human induced pluripotent stem cells (hiPSCs); (2) clonal selection, genotyping, quality control, and banking of gene-edited lines; (3) differentiation, quality control, and banking of hiPSCs into cardiomyocytes; (4) generation and physiological characterization of three dimensional engineered heart tissues (3D-EHTs); (5) pre- and post-operative care of rodents subjected to experimental myocardial infarction and cell transplantation; (6) maintaining accurate experimental records and reagent inventories, analyze results, and present their work during regular lab meetings; and (7) assisting with the routine operations of the laboratory, including ordering, inventory management, supervision of undergraduate student helpers, and preparation of materials and reagents.
Bachelor’s Degree in Molecular, cellular and developmental biology (or a closely related field) and at least one year job experience in molecular cloning and mammalian cell culture. Strong communication and organizational skills.
Familiarity with culture of human induced pluripotent stem cells (hiPSCs). Familiarity with differentiation of hiPSCs into cardiomyocytes. Experience in laboratory management.
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Founded in 1861, the University of Washington is one of the oldest public institutions in the west coast and one of the preeminent research universities in the world. The University of Washington is a multi-campus university comprised of three different campuses: Seattle, Tacoma, and Bothell. The Seattle campus is made up of sixteen schools and colleges that serve students ranging from an undergraduate level to a doctoral level. The university is home to world-class libraries, arts, music, drama, and sports, as well as the highest quality medical care in Washington State and a world-class academic medical center. The teaching and research of the University’s many professional schools provide undergraduate and graduate students the education necessary toward achieving an excellence that will serve the state, the region, and the nation. As part of a large and diverse community, the University of Washington serves more students than any other institution in the Northwest.