Research - Laboratory/Non-Laboratory, Staff/Administrative
Rutgers, The State University of New Jersey is seeking a Postdoctoral Fellow for the Department of Biochemistry and Molecular Biology within Rutgers, Robert Wood Johnson Medical School.
The Patel laboratory (http://www.smitapatelab.org/) is recruiting Postdoctoral Fellows to work on one of three ongoing research projects. The candidates should have a PhD in life sciences and a strong background in biochemical and molecular biology methods to study proteins and nucleic acids.
Among the key duties of this position are the following:
One project involves studying the regulation of the human mitochondrial DNA transcription process, which is responsible for the production of essential gene products for ATP synthesis.
The second project involves studying the initiation of the human mitochondrial DNA replication process responsible for the proper maintenance of the mitochondrial DNA copy numbers in the cells. Mutations in the genes responsible for the transcription and replication of the mitochondrial DNA are associated with numerous mitochondrial related neuromuscular diseases with poor understanding. The project involves reconstituting protein complexes and using biochemical and biophysical methods to study protein-DNA interactions, quantitative time resolved methods to elucidate reaction pathways and enzyme mechanisms, and cryoEM methods to elucidate structures of protein-DNA complexes.
The third project involves studying the RIG-I family viral sensors of the innate immune system to understand its activation mechanism for developing broad spectrum antiviral agents. The project involves developing new assays to probe the autoinhibition and activation mechanisms of the viral sensors, structural analysis (X-ray and CryoEM), quantitative protein-RNA interactions, kinetic analysis of the ATPase and helicase activities, and cell based assays to probe the signaling pathway.
Engage in scientific communication, training of junior personnel, grant writing and manuscript preparation.
Participate in the evaluation of existing procedures, suggesting revisions where necessary and proposing new procedures where required. Assists in the implementation of the programs and projects in special areas of interest to the laboratory.
Minimum Education and Experience:
Ph.D. degree in life sciences, or similar, and a passion for scientific discovery.
Significant experience in the study of proteins and nucleic acids.
Required Knowledge, Skills, and Abilities:
Energetic, collegial, detail oriented and organized.
Physical Demands and Work Environment:
Standing, sitting, walking, talking or hearing. No special vision requirements.
Radioactivity and hazardous chemicals are used in the laboratory. Lab environment; moderate noise.
Salary: $53,760 /annual
Posting Number: 21ST1571
Location: Downtown New Brunswick
Internal Number: 134564
About Rutgers University
Rutgers, The State University of New Jersey, is a leading national public research university and the state's preeminent, comprehensive public institution of higher education. Rutgers is dedicated to teaching that meets the highest standards of excellence; to conducting research that breaks new ground; and to turning knowledge into solutions for local, national, and global communities. As it was at our founding in 1766, the heart of our mission is preparing students to become productive members of society and good citizens of the world. Rutgers teaches across the full educational spectrum: preschool to precollege; undergraduate to graduate and postdoctoral; and continuing education for professional and personal advancement. Rutgers is New Jersey's land-grant institution and one of the nation's foremost research universities, and as such, we educate, make discoveries, serve as an engine of economic growth, and generate ideas for improving people's lives.