The Antibody and Bioresource Core Facility is looking for an individual to support two key services within the core facility, specifically the Custom Monoclonal Antibody Development and the Cell Line Distribution Services. For the former, this individual will be responsible for building out the screening arm of the service to include antibody techniques such as flow cytometry, whole cell ELISAs, immunofluorescence and other cell-based assays at in a multi-well plate format. They will also work side-by-side with a staff member to provide this service, which involves some animal work, a culturing hybridomas, managing multiple projects in parallel over the course of many months and working closely with researchers. The person who assumes this role will also work closely with the core director to provide the Cell Line Distribution Service, which involves on-boarding and distributing published cell lines developed by researchers at Memorial Sloan Kettering Cancer Center (MSKCC) and The Rockefeller University (RU) around the world.
Screen sera and media for antibodies that bind the target using techniques such as standard ELISA, whole cell ELISA, flow cytometry, immunofluorescence and other cell-based assays.
Immunize, bleed and harvest tissue from mice, rats and hamsters.
Perform electrofusions, culture hybridomas, operate a ClonePix FL and cryopreserve hybridomas
Help create and maintain cell line information sheets and institutional databases
Establish cell line stocks, which are authenticated beyond simple STR profiles whenever practical
Maintain accurate laboratory and billing records
Function as an integral facility team member, which minimally involves participating in standard laboratory activities and working with other staff members in support of other services provided by the core, such and antibody purification and the development of new monoclonal antibodies
For Senior Research Assistant level, a Bachelors in Biology or closely related major with 10+ years biomedical laboratory experience or a Masters in Biology or closely related field with 7+ years biomedical laboratory experience.
For Senior Research Scientist level, a Doctorate in Biology or closely related major
A deep understanding of at least one antibody-based technique
Screening experience is an advantage
A breadth of experience culturing and characterizing cell lines
Experience in pharmaceutical company or biotechnology start up is an advantage
A solid appreciation of intellectual property concepts relevant to tangible research material is an advantage #LI-POST
Internal Number: 2021-50655
About Memorial Sloan-Kettering Cancer Center
As one of the world's premier cancer centers, Memorial Sloan-Kettering Cancer Center is committed to exceptional patient care, leading-edge research, and superb educational programs. The close collaboration between our physicians and scientists is one of our unique strengths, enabling us to provide patients with the best care available today as we work to discover more effective strategies to prevent, control, and ultimately cure cancer in the future. Our education programs train future physicians and scientists, and the knowledge and experience they gain at Memorial Sloan-Kettering has an impact on cancer treatment and the biomedical research agenda around the world.