A postdoctoral fellowship is available in the Department of Medical and Molecular Genetics at the Indiana University School of Medicine (IUSM). This candidate will direct studies using in vitro and in vivo approaches for understanding the fundamental biological role of miR-29 in pancreatic diseases with specific focus on pancreatic cancer and pancreatitis using miR-29 KO and genetically engineered murine models, biochemical and molecular genetics. In addition, the candidate will be involved in performing pre-clinical studies to evaluate the therapeutic use of miR-29 and other anti-fibrotic siRNA molecules using AAV gene therapy and pharmacological based approaches.
IUSM has excellent resources with dedicated pancreatic cancer and pancreatitis working groups composed of diverse basic and clinical expertise and availability of cell lines, animal models and human tissue specimens. In addition, IUSM has state of the art research facilities and the Department of Medical & Molecular Genetics houses the viral vector production facility. Further PI is a member of IU Simon Comprehensive Cancer Center and access to a wide variety of research facilities. Together IUSM is creating an excellent environment for trainees too conduct basic and transitional research.
The applicant should have the ability to work independently as well as in collaborative research projects. Duties and responsibilities are to perform experiments in a basic cancer biology research laboratory for in vivo characterization of mouse models, as well as cell culture experiments. Techniques include using transgenic and knockout mice for in vivo/ex vivo experiments, serum and tissue sample collection and analysis, cell culture, molecular cloning, generation of stable cell lines, CRISPR, RNA-Seq, scRNAseq IP/CLIP, transfection, qPCR, ddPCR, immunoblot, immunohistochemistry, and bioinformatics analysis.
As the nation's largest medical school, IUSM is committed to being an institution that not only reflects the diversity of the learners we teach and the patient populations we serve, but also pursues the values of diversity, equity and inclusion that inform academic excellence. We desire candidates who enhance our representational diversity, as well as those whose work contributes to equitable and inclusive learning and working environments for our students, staff, and faculty. IUSM strives to take an anti-racist stance, regularly evaluating and updating its policies, procedures, and practices to confer equitable opportunities for contribution and advancement for all members of our community. We invite individuals who will join us in our mission to advance racial equity to transform health and wellbeing for all throughout the state of Indiana.
Doctorate or terminal degree required. PhD or MD PhD in Biology/Genetics/Molecular Biology/Cell Biology/Biochemistry or a related field.
Department Contact for Questions:
For inquiries about this position, please contact Dr. Janaiah Kota e-mail firstname.lastname@example.org
OAA #: IUSM010912016
Internal Number: 11007
About Indiana University Purdue University Indianpolis - IUPUI
Founded in 1820, Indiana University is the state’s public university system, comprised of two core campuses—IU-Bloomington and IUPUI—and six regional campuses located throughout the state. Combined, the total student population is more than 114,000 undergraduate, graduate and professional school students. IU is one of the largest employers in the state, with over 20,000 faculty and staff. Indiana University is an equal employment and affirmative action employer and a provider of ADA services. Diversity and inclusion remains a core commitment to IU’s mission to cultivate an educational environment that supports equal access, participation and representation on all of its campuses and that provides educational and career opportunities for all.