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If you're ready to be a part of breakthrough research, then we invite you to consider this exciting opportunity and apply today!
The Department of Neurosurgery is committed to bringing the best and brightest minds together to advance care for cancer, Alzheimer's disease and Parkinson's disease, among other challenging health issues.
A Postdoctoral Scientist position in computational neuroscience and biophysics of human cortical processing is open for a joint computational project between the teams of Costas Anastassiou, PhD, and Ueli Rutishauser, PhD. The Anastassiou team employs multi-modal, single-cell investigations in human circuits to understand cortical function and dysfunction as occurring in diseases like epilepsy. The Rutishauser lab investigates the mechanisms of learning, memory, and decision-making with a particular interest in the human brain at the single-neuron level.
In this role, you will be an essential team member in our ongoing effort to understand human brain function spanning across spatiotemporal scales. The core responsibility for this position is to set-up computational simulations and data analysis workflows from slice and in vivo brain physiology in humans.
More specifically, this position will be responsible for the following:
Design and conduct biophysical simulations with an existing computational framework allowing simulation of reconstructed, interconnected and biophysically realistic human neurons (e.g. [Reimann, Anastassiou et al, Neuron, 2013; Nandi et al, bioarxiv, 2020].
Analyze simulated and experimental data using state-of-the-art statistical analyses to establish structure-function relationships (e.g. [Mosher, Wei et al, Cell Reports, 2020]).
Compare computational findings with experimental observables to deduce biophysical principles of high-level functioning [Minxha et al, Science, 2021]. Of particular interest will be how cellular, cell type and whole circuit functioning is manifested in the extracellular field in humans.
Primary Job Duties and Responsibilities:
In close collaboration with theoreticians and experimental colleagues, design, implement and conduct single-neuron and network simulations of human neurons.
Contribute to ongoing efforts in computational framework development (simulation and data analysis) as well as to scientific questions relevant to the system under investigation.
Contribute to adjacent projects related to human pathophysiology and neurotherapies.
Publish/present findings in peer-reviewed journals/scientific conferences.
Prepare written and oral reports.
Maintain clear and accurate communication with supervisor, team members and external collaborators.
Works independently on research projects designed by PI within area of specialization.
Doctorate (MD, PhD, VMD or DDS) in area directly related to field of research specialization, required.
PhD degree in computational neuroscience, physics, applied mathematics, bioengineering or related field, highly preferred.
Experience and Skillset:
Strong background in scientific computing; experience in computational neuroscience is preferred, but other strong applicants will be considered (with background in computational physics, applied mathematics, biophysics, and related disciplines).
Experience with parallel computing is a plus as well as familiarity with high-level programming languages such as Python or Matlab.
Familiarity with in vitro and in vivo electrophysiological monitoring techniques and analysis.
Acquires strong technical and theoretical knowledge of research project and objectives during one to five (1-5) year post-doctoral appointment.
Demonstrated aptitude to perform experimental protocols and procedures, including detailed data collection, analysis, operation, knowledge of safety standards and maintenance of specialized equipment.
Ability to meet aggressive timelines and deliverables in a collaborative environment.
Strong publication record.
Experience in pursuing research projects in collaborative fashion.
Proven independent thinking and flexibility.
Strong written and verbal communication skills.
Able to perform moderate lifting. Able to sit, stand and walk for prolonged periods of time. Able to read papers and online documents. Able to operate standard office equipment. Able to exercise physical ability and perspective acuity to satisfactorily perform essential job functions.
Working Title: Postdoctoral Scientist (Computational Neuroscience/Biophysics research experience) - Anastassiou & Rutishauser Labs - Department of Neurosurgery
Providing healthcare for more than 100 years, Cedars-Sinai has evolved into one of the most dynamic and highly renowned medical centers in the world. Along with caring for patients, Cedars-Sinai is a hub for biomedical research and a training center for future physicians and other healthcare professionals. This attracts exceptional talent to Cedars-Sinai, including world-renowned physician-scientists who seek a place where they can both conduct research and see patients--the ideal formula for discovery and its translation into cures. Our patients benefit from access to doctors at the top of their fields, and our researchers have an ideal community in which to study the impact of healthcare challenges, and reflect that knowledge in their research. The greater Los Angeles area in which Cedars-Sinai resides possesses unparalleled cultural and ethnic diversity which offers outstanding opportunities for translational and clinical research and a dynamic environment for medical education.Although community based, Cedars-Sinai is a major t...eaching hospital affiliated with the David Geffen School of Medicine at the University of California, Los Angeles (UCLA). Cedars-Sinai has highly competitive graduate medical education programs in more than 50 specialty and subspecialty areas, a graduate program in biomedical sciences and translational medicine, a clinical scholars program directed towards junior physicians with aspirations to become clinical scientists, and post graduate training opportunities.There are more than 250 full-time faculty members at Cedars-Sinai. The voluntary medical staff, comprised of more than 2,200 specialty board-certified or board-qualified physicians, represent all of the specialties and subspecialties and collaborate with full-time medical staff in the teaching responsibilities of the graduate medical education programs.