The Center for Bioinformatics and Functional Genomics at Cedars-Sinai Medical Center is seeking a Postdoctoral Scientist to join the labs of Drs. Simon Gayther and Simon Knott!
Our Center brings together teams specializing in cell biology, computational biology, functional analysis of the genome coupled with next generation genome to cover all aspects related to identifying cancer risk loci and understanding their mechanistic and phenotypic consequences.
Dr. Gayther's research program is largely focused on understanding the underlying causes of ovarian, breast, and prostate cancer development. The lab is working to define the heritable component and the functional role of both common and rare risk variants and their target susceptibility genes in the early stage disease pathogenesis.
Dr. Knott's research program is focused on developing and apply computational and molecular tools to study cancer progression. His laboratory is primarily focused on understanding the hetero-cellular interactions that drive cancer progression, with the overreaching goal of improving patient outcomes by targeting these relationships. The projects within the laboratory span a spectrum of disease stages, from the analysis of tissues that capture disease initiation to the profiling of late stage metastases. They study animal models and clinical samples with high-fidelity analysis tools and then test hypotheses generated from this work using the functional genetic tools they continue to develop. For more information, please visit https://www.cedars-sinai.org/research/labs/knott.html
Working independently but in close cooperation and in consultation with the Principal Investigators and other Research Scientists, the Postdoc will perform routine and complex laboratory procedures throughout training period, and may develop, adapt, and implement new research techniques and protocols. This role analyzes and interprets data, may assist in preparation of grant proposals, and participates in publications and presentations as author or co-author. This position is not responsible for generating grant funds.
Primary Duties and Responsibilities:
Design, implement and execute CRISPR screens
Manage the day to day running of downstream experiments
Abide by Animal Licenses, IRB protocols, and SOP relating to projects in the laboratory
Supervise a graduate student/RA on relevant projects
Undertake research projects that are part of the research program under the direction of principal Investigators
Present at national/international conferences and give internal seminars
Assist in day to day activities in running the laboratory
Doctorate (MD, PhD, VMD, or DDS) in area directly related to field of research specialization
Experience and Skillset:
Experience in genetics, genomics and genome editing
Experience in generally molecular biology techniques such as PCR, cloning, plasmid manipulation, siRNA/CRISPR knockdown
Experience in cell culture, cell biology assays and modeling of disease
Experience in high throughput screening approaches
Experience in generating next generation sequencing data
Working Title: Postdoctoral Scientist - Gayther/Knott Lab - Center for Bioinformatics and Functional Genomics
Providing healthcare for more than 100 years, Cedars-Sinai has evolved into one of the most dynamic and highly renowned medical centers in the world. Along with caring for patients, Cedars-Sinai is a hub for biomedical research and a training center for future physicians and other healthcare professionals. This attracts exceptional talent to Cedars-Sinai, including world-renowned physician-scientists who seek a place where they can both conduct research and see patients--the ideal formula for discovery and its translation into cures. Our patients benefit from access to doctors at the top of their fields, and our researchers have an ideal community in which to study the impact of healthcare challenges, and reflect that knowledge in their research. The greater Los Angeles area in which Cedars-Sinai resides possesses unparalleled cultural and ethnic diversity which offers outstanding opportunities for translational and clinical research and a dynamic environment for medical education.Although community based, Cedars-Sinai is a major t...eaching hospital affiliated with the David Geffen School of Medicine at the University of California, Los Angeles (UCLA). Cedars-Sinai has highly competitive graduate medical education programs in more than 50 specialty and subspecialty areas, a graduate program in biomedical sciences and translational medicine, a clinical scholars program directed towards junior physicians with aspirations to become clinical scientists, and post graduate training opportunities.There are more than 250 full-time faculty members at Cedars-Sinai. The voluntary medical staff, comprised of more than 2,200 specialty board-certified or board-qualified physicians, represent all of the specialties and subspecialties and collaborate with full-time medical staff in the teaching responsibilities of the graduate medical education programs.