Research - Laboratory/Non-Laboratory, Staff/Administrative
A Research Lab Technician Intermediate position is available in the Michigan Center for Translational Pathology (MCTP), under the direction of Arul Chinnaiyan, MD, PhD. We are seeking an energetic, highly motivated individual to assist us in our projects focused on cancer biology and therapeutics. The candidate will perform routine laboratory experimental procedures in one or more areas of work under the supervision of the Principal Investigator. At MCTP, we are committed to development of novel therapeutic agents involved in a wide variety of diseases, including prostate cancer, pediatric cancer pancreatic cancer, and lung cancer.
Routine cell culture maintenance: passaging of adherent and suspension cells, freezing and recovering cell lines.
In vitro high throughput screening of small molecule: determine and calculation of IC50 in 96 well formats, incucyte assay and crystal violet staining.
Functional assay: Protein and RNA extraction from cells and tumor tissue, western blotting, confocal microscopy, qPCR, cell migration and invasion assay.
In vivo work: basic mouse handling skills such as restraint of various strains of mice, ear tagging of young and adult mice; establish various tumor models such as tumor cell injection by subcutaneous, tail vein, intracardiac; tumor measuring through digital caliper or bioluminescent imaging; therapeutic drug preparation and dosing through different routes such as oral gavage, intraperitoneal, subcutaneous, tail vein; perform animal necropsy and tissue/organ collection.
Immunohistochemistry: processing of fixed tissues and diverse staining procedures.
Train and manage undergraduate research students.
Maintain lab equipment and organize sample inventory.
Draft and maintain lab protocols.
BS degree in cell/molecular biology or similar field.
Two to three years of relevant experience in cancer research.
Experience in mammalian cell culture, nucleic acid and protein isolation, qPCR, western blotting.
Experiences in drug efficacy/therapeutic studies.
Basic mouse handling skills.
Strong organizational and multi-tasking skills.
Excellent documentation skills for research results.
Excellent teamwork and communication skills.
Excellent time management skills.
Willing to have some schedule flexibility and occasionally work on weekends.
Knowledge and understanding of laboratory safety and ability to work carefully with potentially harmful agents.
Ability to function independently as well as a team member in a team setting.
Must possess energy and drive to coordinate multiple projects simultaneously.
Demonstrated ability to learn new and innovate processes.
Maintain detailed records of bench work and in vivo work on notebook and online database.
Familiar with Microsoft office (Word, Excel, and PowerPoint), GraphPad Prism, PubMed or other literature search portals.
Michigan Medicine conducts background screening and pre-employment drug testing on job candidates upon acceptance of a contingent job offer and may use a third party administrator to conduct background screenings. Background screenings are performed in compliance with the Fair Credit Report Act. Pre-employment drug testing applies to all selected candidates, including new or additional faculty and staff appointments, as well as transfers from other U-M campuses.
Michigan Medicine improves the health of patients, populations and communities through excellence in education, patient care, community service, research and technology development, and through leadership activities in Michigan, nationally and internationally. Our mission is guided by our Strategic Principles and has three critical components; patient care, education and research that together enhance our contribution to society.
Job openings are posted for a minimum of seven calendar days. The review and selection process may begin as early as the eighth day after posting. This opening may be removed from posting boards and filled anytime after the minimum posting period has ended.
The University of Michigan is an equal opportunity/affirmative action employer.
Internal Number: 199196
About University of Michigan - Ann Arbor
A great university is made so by its faculty and staff, and Michigan is recognized as one of the best universities to work for in the country. The Michigan culture is known for engaging faculty and staff in all facets of the university to create a workplace that is vibrant and stimulating.For two consecutive years, the Chronicle of Higher Education has placed U-M in its "Great Colleges to Work For" survey. In particular, the university earns high marks for strong relations between faculty and administrators, a collaborative system of governance, strong pay and benefits, and a healthy work/life balance.