To conduct research in bio-engineered Alzheimer's Disease (AD) recapitulated brain organoid and further brain chip to study to elucidate novel mechanisms underpinning human AD. The Postdoc, working independently but in close cooperation and consultation with the Principal Investigator and other Scientists, will perform routine and complex laboratory procedures throughout training period and may develop, adapt, and implement new research techniques and protocols. This position will design and perform experiments on vascularized organoids derived from iPSC and further construction of brain chip, including the iPSC-based organoid generation, vascularization and immune cells interaction. Functional analysis of these brain organoids by 3D culture, live cell imaging, ICC, confocal/light sheet imaging, ELISA, flow cytometry RT-PCR, and western blot will also be required.
Primary Function of Organizational Unit:
The FITBEST lab develop vascularized brain organoids to recapitulate Alzheimer's disease and study phenotypic expression of AD in terms of 1) tissue chip utilization with engineered extracellular matrix, 2) blood brain barrier dysfunction, 3) overactive inflammatory behavior induced by microglia and circulating immune cells, 4) efficacy of treatments.
Internal job number: 009723
Doctorate (PhD) in related field. Works independently on research projects designed by a mentor (typically the PI) within area of specialization. Acquires thorough technical and theoretical knowledge of research project and objectives during one to five (1-5) year post-doctoral appointment. Candidate must have: (1) demonstrated aptitude to perform experimental protocols and procedures, including detailed data collection, and analysis, operation and maintenance of specialized equipment, (2) Knowledge of safety standards; and (3) Excellent written and oral communication skills.
Ph.D. in Engineering
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North Carolina Agricultural and Technical State University is one of the nation’s most highly respected doctoral research, land-grant institutions. With an enrollment of almost 11,000 students, we are committed to fulfilling our mission through exemplary undergraduate and graduate instruction, scholarly and creative research, and effective public service. As a member of the A&T family you will be an integral part of its history and future – joining more than 1,800 current faculty and staff. You will be expected to be a leader and mentor. You will influence the minds that will affect our world. As a change agent, you will use your intellect and influence to make a positive impact on the greater A&T community. A&T will be more than your job, it will become your passion—and that commitment to yourself and others will last a lifetime. Because that’s what Aggies Do!