Research - Laboratory/Non-Laboratory, Staff/Administrative
Department: MED-Neurological Surgery Salary/Grade: NEX/9
Job Summary:The laboratory of Dr. Peiwen Chen in the Feinberg School of Medicine Department of Neurological Surgery conducts basic and translational studies focusing on tumor immunology and immunotherapy in brain tumor. Current research in our lab focuses on studying how genetic and epigenetic regulation of cancer cells and/or cancer stem cells can shape an immunosuppressive tumor microenvironment (TME), and reciprocally, how these immune cells affect tumor progression and the effectiveness of immunotherapy. We use unbiased approaches (microarray, RNA-Seq, scRNA-Seq, ChIP-Seq and CyTOF) to identify novel molecular and cellular events in brain tumor with different treatments and/or backgrounds. Functional validation of results using standard molecular biology techniques will be performed in vitro and in vivo using patient derived xenograft line, primary samples and murine models. The Research Technologist will study the molecular mechanisms that underlie the interaction between cancer cells and immune cells in the TME, and utilize state-of-the-art facilities to conduct cutting-edge research with the intention of publishing the results in pre-eminent peer-reviewed scientific journals.Specific duties include: conducts tests and procedures; sets up and operates equipment; records observations and measurements and collects as well as compiles data; conduct basic animal and experimental research lab work and/or assist in one or more phases of specific projects. Principal accountabilities include: following pre-defined protocols, policies, procedure, regulations, and Good Clinical and Good Laboratory Practices; conducting standard and repetitive experiments and completing basic trouble-shooting techniques; setting up, operating and maintaining standard lab equipment; and using an entry-leve of skill, peforming Molecular Biology (DNA, RNA, Protein isolation, purification and expression Southern, Northern, Western blotting; PCR, RT-PCR; Plasmid preparation; Cloning, mapping, and sequencing of DNA; Recombinant virus production and purification); Cellular Biology (Cell culture, cell isolation; Functional studies; Transfection); and Animal techniques (Husbandry, Breeding and screening transgenic mice; Dissections; Blood collection; Surgical procedures; Database management of colony).
Minimum Qualifications:HS diploma or equivalent and some basic science courses is required.
Preferred Qualifications:Bachelor’s degree in relevant field (cell biology, molecular biology, genetics, biophysics, etc.); Experience working on basic or translational cancer research; Experience working in a laboratory environment with mouse models.
Demonstrated ability to follow detailed instructions and research protocols.
Demonstrated computer proficiency, including spreadsheets and word processing.
Attention to detail, ability to ensure ongoing organization of laboratory environment.
Precise and accurate record keeping, adherence to ethical standards of research.
Ability to work reliably, both independently and in a team environment.
Ability to assist and train other lab members in routine protocols.
Ability to build rapport with faculty and ancillary staff.
Ability to comprehend and critique published scholarly articles.
Familiarity and experience with animal care and tissue culture methods.
Excellent organizational, oral and written communication skills.
High familiarity with use of Microsoft Office programs (Word, Excel, PowerPoint).
Above average planning, organization and time management skills.
Knowledge of and adherence to safety and regulatory compliance.
Northwestern University is an Equal Opportunity, Affirmative Action Employer of all protected classes, including veterans and individuals with disabilities. Women, racial and ethnic minorities, individuals with disabilities, and veterans are encouraged to apply. Hiring is contingent upon eligibility to work in the United States.
Internal Number: 40983
About Northwestern University
Northwestern University is a major private research university with 12 academic divisions located on three campuses in Evanston, Chicago, and Education City in Doha, Qatar. We have approximately 2,500 full-time faculty members, 17,000 graduate and undergraduate students, and over 5,700 full and part-time staff. Northwestern University combines innovative teaching and pioneering research in a highly collaborative environment. It provides students and faculty exceptional opportunities for intellectual, personal and professional growth.