The University of Southern California (USC), founded in 1880, is located in the heart of downtown L.A. and is the largest private employer in the City of Los Angeles. As an employee of USC, you will be a part of a world-class research university and a member of the âTrojan Family," which comprises the faculty, students, and stage that make the university what it is.
The Kuhn-Hicks Laboratory at USC Michelson Center Convergent Science Institute in Cancer (CSI-Cancer) is studying circulating tumor cells (CTCs) in the liquid biopsies (blood and bone marrow) of cancer patients as an approach to manage cancer care. Our single-cell multi-omic approach allows us to look at the morphology, proteome, and genome of these CTCs individually. Collectively, this information permits an understanding of the disease in hopes of enabling personalized medicine in oncology.
Our effort is led by a multidisciplinary team of scientists and physicians across the nation. We have multiple ongoing clinical studies to explore the utility CTCs in different cancers. We are currently searching for an energetic, passionate, dedicated, and experienced scientific core manager who has a keen interest in working with a large dynamic group and cutting edge technologies. The qualified candidate will play a vital role in managing the full sample processing pipeline and processes, along with carrying out other essential duties in the lab. The qualified candidate will directly report into the leadership team of the institute and will have the opportunity to directly interface with students and postdoctoral fellows on research projects.
Duties & Responsibilities:
Responsible for HDSCA liquid biopsy core operations:
Organizes and oversees the flow of samples through the HDSCA pipeline and performs troubleshooting of pipeline operations.
Develops and implements operating procedures and standards to ensure laboratory operations and overall organization.
Equipment management: includes but not limited to: yearly freezers/fridges maintenance, pipette calibration, biosafety hood, incubators, and staining instrument calibrations/certifications.
Clinical Sample Operations: daily communication with the various couriers and the clinical sites to ensure biological sample arrival is received within 24hr of patient draw point for processing; manages weekly/monthly clinical inventory and sending/receiving schedule of clinical supplies to the collaborating clinical sites; updates collaborators on the current biospecimen repository. Operationalize new studies: this includes but not limited to sending SOPs for assembling and shipping instructions to clinical sites, arranging shipping procedures and labels, and updating database entries.
QA/QC: conducts daily, weekly, monthly, and yearly quality assurance/controls on the general sample processing pipeline and creates SOPs. Includes but not limited to data entry (accurately match and record all samples in our database system), sample results/scanner reports QC analysis and validation, instrument logs, equipment, yearly throughput (supplies, staining batches, and scans run)
Controls equipment and supplies inventory. Recommends purchase, locates, negotiates prices, and orders equipment and supplies for funded research projects.
Hires, trains, assigns, prioritizes and schedules work of technical team. Assesses performance and gives feedback.
Supervision: supervise laboratory technicians in sample processing and genomics workflow.
Onboarding & Training: ensure required training and documents to work in the lab (Safety training, SOP, lab access). This position serves as the Safety Officer adhering to current USC safety policies and procedures in the laboratory. This person will provide annual safety training and be responsible for maintaining laboratory safety in compliance with university policies.
Develops and implements security related procedures such as office opening and closing routines, recognition of duress signals and key controls. Coordinates security activities with the University Public Safety Department. Promotes and maintains standards for security conscious awareness and behavior. Maintains knowledge of Universityâs crime prevention and suppression programs and services. Ensures dissemination of security related information to staff.
Other: must present and update the lab members on progress, timeline, and deadlines of the processing workflow during weekly meetings; accurately records and documents issues and important information in the laboratory notebook; Ability to prioritize, organize, and handle high volume/tasks workload efficiently while meeting strict deadlines; Experience providing direct feedback and training to team members; ability to coach and mentor more junior technicians and students. Performs other related duties as assigned or requested. The University reserves the right to add or change duties at any time.
***Interested individuals should provide their CV and a 1-2 page cover letter describing their professional goals and how their laboratory experience can advanceÂ CSI-Cancerâs mission. ***
Possess excellent interpersonal communication skills with a high emphasis on collaboration, meticulous attention to detail, competent at working independently, and the ability to quickly adapt to a broad scope of projects.
Fully competent and proficient in the operation of sophisticated scientific equipment and independently able to perform complex procedures and techniques with accuracy.
Bachelor's degree in Biology, Molecular Biology, Biochemistry or related Biological Science area or equivalent experience.
Background in immunofluorescence assay operation, development and troubleshooting procedures.
Must be a highly motivated individual with acute attention to detail, and able to work with minimal oversight to complete deadlines.
PhD degree or equivalent combination of education, training, and experience.
Experience in a BSL-2 laboratory setting.
Will be working with liquid biopsies (blood, bone marrow aspirate, etc), tissue, and cell lines.
Must have a reliable means of transportation to retrieve packages containing biological substances at a local courier facility.
Adhere to our Environmental Health and Safety to monitor safe storage and disposal of chemicals.
Must comply with General Lab Safety, Blood Borne Pathogens.
The work schedule may include weekends.
On-site location only (no remote work).
Must be able to stand and/or sit for extended periods of time.
Must be able to carry and lift 10-20 pounds regularly.
Required Documents and Additional Information:
Resume and cover letter required (may be uploaded as one file). Please do not submit your application without these documents.
Job openings are posted for a minimum of (5) five business days. This job may be removed from posting boards and filled any time after the minimum posting period has ended, so please apply on the same business day if interested.
USC has excellent benefits, including health benefits for staff and their family with access to the renowned university medical network; eligibility for retirement plans with employer contributions after six months of employment; tuition benefits for staff and their family; free Professional Development classes; central Los Angeles location with easy access to commuter trains, buses and free tram pick up services; discounts to sporting and other campus events.
The University of Southern California is an Equal Opportunity Employer that Values Diversity.
Minimum Education: Bachelor's degreeMinimum Experience: 7 yearsMinimum Field of Expertise: Specialized, progressively responsible experience in laboratory instrumentation
USC is the leading private research university in Los Angeles—a global center for arts, technology and international business. With more than 47,500 students, we are located primarily in Los Angeles but also in various US and global satellite locations. As the largest private employer in Los Angeles, responsible for $8 billion annually in economic activity in the region, we offer the opportunity to work in a dynamic and diverse environment, in careers that span a broad spectrum of talents and skills across a variety of academic and professional schools and administrative units. As a USC employee and member of the Trojan Family—the faculty, staff, students, and alumni who make USC a great place to work—you will enjoy excellent benefits, including a variety of well-being programs designed to help individuals achieve work-life balance.