Cedars-Sinai Cancer is committed to pursuing pioneering research into disease mechanism, diagnostic innovations and new technologies and resources. Through our historic achievements, growing research enterprise, and serving one of the most diverse regions in the world, our physicians and scientists are uniquely positioned to guide the next generation of progress against the disease.
Join our team and use your expertise with an organization known nationally for excellence in cancer research.
The Merchant lab seeks a post-doctoral fellow with an interest in hematopoiesis, stem cell biology, and/or myeloproliferative diseases to join an NIH funded project examining the role of Hedgehog signaling in the bone marrow microenvironment. Studies in the lab make use of transgenic mouse models and primary patient samples. There will be additional opportunities to study patient samples from patients treated with hedgehog inhibitors. Studies of the bone marrow microenvironment will be enabled but the use of imaging mass cytometry/CyTOF. Imaging mass cytometry allows for highly multiplexed (35+ markers) imaging of immune and tumor cells, with spatial information and subcellular resolution making it the ideal technology for studying stem cells and immune cells in their cellular niches within the bone marrow. Imaging mass cytometry can be applied to all tissue types including cell lines, organoids, frozen section and FFPE fixed archival tissue.
Perform experiments with transgenic mice including breeding, genotyping, blood sampling and bone marrow harvesting.
Apply standard molecular and cellular biology methods (RT-PCR, Western bloting, cell culture and transduction, expression profiling) to profile the hedgehog signaling pathway.
Use imaging mass cytometry to study the bone marrow microenvironment and stromal cell changes in animal models of myelofibrosis and in patient samples.
Will assist in preparation of grant proposals, but is not responsible for generating grant funds. Will be encouraged to apply for fellowships as part of career development
Will participate in publications and presentations as author or co-author.
May train and supervise laboratory assistants and/or graduate students
Designs and performs experiments. Will keep appropriate experimental records and documentation and analyze the results with the Principal Investigator.
May develop, adapt, and implement new research techniques and protocols.
Analyzes, interprets, summarizes and compiles data.
Performs routine and complex laboratory procedures throughout training period.
Operates and maintains equipment and instruments.
Doctorate (MD, PhD, VMD, or DDS) in area directly related to field of research specialization.
Works independently on research projects designed by a mentor (typically the PI) within area of specialization.
Acquires thorough technical and theoretical knowledge of research project and objectives during one to five (1-5) year post-doctoral appointment.
Demonstrated aptitude to perform experimental protocols and procedures, including detailed data collection, and analysis and operation and maintenance of specialized equipment.
Working Title: Postdoctoral Scientist - Dr. Merchant Lab
Providing healthcare for more than 100 years, Cedars-Sinai has evolved into one of the most dynamic and highly renowned medical centers in the world. Along with caring for patients, Cedars-Sinai is a hub for biomedical research and a training center for future physicians and other healthcare professionals. This attracts exceptional talent to Cedars-Sinai, including world-renowned physician-scientists who seek a place where they can both conduct research and see patients--the ideal formula for discovery and its translation into cures. Our patients benefit from access to doctors at the top of their fields, and our researchers have an ideal community in which to study the impact of healthcare challenges, and reflect that knowledge in their research. The greater Los Angeles area in which Cedars-Sinai resides possesses unparalleled cultural and ethnic diversity which offers outstanding opportunities for translational and clinical research and a dynamic environment for medical education.Although community based, Cedars-Sinai is a major t...eaching hospital affiliated with the David Geffen School of Medicine at the University of California, Los Angeles (UCLA). Cedars-Sinai has highly competitive graduate medical education programs in more than 50 specialty and subspecialty areas, a graduate program in biomedical sciences and translational medicine, a clinical scholars program directed towards junior physicians with aspirations to become clinical scientists, and post graduate training opportunities.There are more than 250 full-time faculty members at Cedars-Sinai. The voluntary medical staff, comprised of more than 2,200 specialty board-certified or board-qualified physicians, represent all of the specialties and subspecialties and collaborate with full-time medical staff in the teaching responsibilities of the graduate medical education programs.