The OHSU Proteomics Shared Resource (PSR) facility was established to make state-of-the-art mass spectrometry-based protein analysis analytical capabilities available to the biomedical research community at OHSU. The PSR provides services to both internal and external clients outside OHSU, including supporting ophthalmological and cancer research by members of the Casey Eye and Knight Cancer Institutes. The PSR Research Associate (RA) will prepare samples for analysis, develop new methods of sample preparation, analyze samples using mass spectrometry, analyze data, provide result summaries to clients, and fully document all experimental work and procedures. They will also prepare standard operating procedures (SOPs); perform maintenance on mass spectrometry instrumentation, train clients on instrument operation and sample preparation, and assist in preparation of methods sections for manuscripts and grants. They will be expected to manage multiple projects within timelines assigned by the director and maintain high scientific and ethical standards. Working collaboratively with team members, the RA will promote a culture of transparency and traceability across all aspects of laboratory operations.
Prepare samples for proteomics analysis by LC/MS using standard operating procedures.
Develop and test new methodologies of sample preparation.
Document experimental work, analyze data, and present results.
Prepare and maintain standard operating procedures (SOPs).
Operate mass spectrometry instrumentation and perform troubleshooting and maintenance as needed.
Assist in the preparation of manuscripts and grant applications.
Other duties as assigned to support the PSR.
Bachelors degree with major courses in field of research
At least 5 years of postgraduate academic or industry experience.
Prior experience in operation of LC/MS systems.
Prior experience in either purification or analysis of proteins.
Knowledge and experience with protein sample preparation methodologies and proteomic workflows
Demonstrated ability to plan and execute research experiments
Ability to manage multiple projects within timelines according to high scientific and ethical standards
Proven collaboration and interpersonal skills to develop and maintain effective working relationships with team members, other OHSU employees, internal and external clients
Excellent verbal and written communication skills
Fast learner, flexible, with ability to make sound decisions and creatively problem solve
Receives occasional supervision
Exercise judgement in taking independent action, and seeks advice as necessary
Assist in planning experimental design
Assume responsibility for specific component of a research project
Responsibility for training clients in sample preparation and supervising students and volunteers
A mindful team member, able to promote a culture of transparency and traceability across all aspects of laboratory operations
Proficiency with MS Office Suite and databases
MS or PhD in Analytical Chemistry or closely aligned field
Extensive knowledge and application of proteomic sample preparation methodologies as applied to protein mass spectrometry workflows, implementing quantitative mass spectrometry-based strategies, including label-free analyses (DIA, PRM/SRM) and labeled (TMT) methods
Experience and knowledge in the operation and maintenance of different types of mass spectrometers, especially high-resolution mass spectrometers (Orbitraps or q-TOF)
Experience with MS software analysis pipelines
Working conditions: Typical weekly work week schedule; may sometimes require work on weekends or after 5 pm.
Physical demands & equipment usage:
Must be able to stand for up to four continuous hours per day. Must be able to communicate orally and in writing the results of scientific experiments; must be able to use a standard computer and screen up to 6 hours per day.
Oregon Health & Science University values a diverse and culturally competent workforce. We are proud of our commitment to being an equal opportunity, affirmative action organization that does not discriminate against applicants on the basis of any protected class status, including disability status and protected veteran status. Individuals with diverse backgrounds and those who promote diversity and a culture of inclusion are encouraged to apply. To request reasonable accommodation contact the Affirmative Action and Equal Opportunity Department at 503-494-5148 or firstname.lastname@example.org.
As the state's only health and research university, OHSU brings together patient care, research, education of the next generation of health care providers and scientists and community service to improve the health and well-being of all Oregonians.The university is a conduit for learning for more than 2,800 students, providing training to interns, residents and fellows in postgraduate medical and research. It is the only place in Oregon that grants doctoral degrees in medicine, dentistry and nursing. OHSU cares for more than 251,000 patients each year from around the region and takes a leadership role in contributing to solutions involving the health of the state and the nation, such as health care access and transparency, ethics and workforce shortage. Beyond providing critical health care services, quality education and cutting-edge research, OHSU also is a key economic and social force in the Northwest. With an annual operating budget of $2.06 billion and more than 14,000 employees, OHSU is Portland?s largest employer. Its size contributes to its ability to provide... many services and community support activities not found anywhere else in Oregon. For more information visit http://www.ohsu.edu/xd/about/index.cfm