There is currently a postdoctoral research scientist position available in the Stem Cell and Cellular Models Platform in the Taub Institute for Research on Alzheimer's Disease and the Aging Brain. The Platform, directed by Dr. Andrew Sproul, serves as a proactive resource to help generate human pluripotent stem cell (PSC) models of Alzheimer's disease (AD) and other neurodegenerative diseases, with a large focus on late-onset AD (LOAD). LOAD risk factors, and other genomic modifications, will be knocked into control PSC backbones using CRISPR/Cas9 technology. These isogenic PSC lines will subsequently be differentiated into disease-relevant cell types in both monolayer and organoid formats for functional assays. Differentiation strategies include overexpression of transcription factors by lentiviral transduction. As these are very collaborative projects with other research groups within the Taub Institute, good communication skills are essential for this position. In addition, leadership and strong organizational skills are required, as the postdoctoral scientist will help manage the day-to-day operations of the Platform and technicians, in coordination with the lab manager. While the primary focuses of the position are to assist with and help manage collaborative projects, as well as to help translate/develop new differentiation protocols, the postdoctoral scientist will also lead more mechanistic studies driven by Dr. Sproul. There is potential for internal advancement.
Conduct research in an independent manner
Lead multiple collaborative projects in parallel
Assist in running the Platform by helping to supervise and guide technicians and research assistants
Assist in manuscript and grant writing
Internal Number: 7624
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