Research - Laboratory/Non-Laboratory, Staff/Administrative
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Special Selection Applicants: Apply by 05/12/21. Eligible Special Selection clients should contact their Disability Counselor for assistance.
The UCSD Department of Pharmacology is one of two basic science units in the School of Medicine where world-class researchers investigate the effects of chemical interventions on biological systems. The faculty are internationally renowned for their strength in elucidating basic cellular and molecular mechanisms of signal transduction that lead to innovative drug target identification and ultimately to cutting edge drug discovery. The faculty also play a major role in medical and graduate student training, providing educational and programmatic offerings that span several disciplines, and provide diversity to meet the interests of a broad spectrum of students and scholars.
More than one hundred trainees at the graduate student and postdoctoral level, as well as a staff of more than 50 research technicians and department administrators interact closely with the faculty. The diverse mix of ages, backgrounds, and talents creates a robust work environment with challenging career opportunities and a commitment to continued growth potential. We constantly seek to recruit highly motivated, technologically-advanced and interested individuals to become a part of our dynamic exploratory research and educational environment.
The successful candidate will serve as an active team member for a comprehensive research program in our laboratory located within the Department of Pharmacology. The research projects involving the study of lipid metabolism, cell signaling and lipid analysis are supervised by Prof. E.A. Dennis and Prof. O. Quehenberger. For the lipidomic studies, we have assembled an advanced analytical platform consisting of high-end mass spectrometry instrumentations. The successful applicant will perform standard laboratory procedures, conduct cell biology experiments, and participate in advanced analytical processes. This will involve organizing cell experiments, performing extraction procedures of biological material, preparing samples, conducting detailed lipid analysis, and assisting with analytical procedures involving gas chromatography and liquid chromatography coupled with mass spectrometry.
Under supervision, the incumbent will participate in the interpretation of mass spectral data and performing bioinformatics analysis using established protocols. Practical knowledge of analytical biochemistry and general computer/software skills are required. Prior experience with mass spectrometry is not required but a strong interest in the technical aspects of mass spectrometry and its application to analytical questions is essential. Under guidance, the incumbent will also perform cellular studies related to lipid metabolism and inflammation. The ability to maintain clear records of experimental work, to organize scientific reports and to communicate the results is necessary. The incumbent will be part of a larger research team and will be afforded all necessary training opportunities.
Theoretical knowledge of molecular biology, chemistry, biology, or biochemistry.
Demonstrated ability to read, comprehend and discuss research materials and effectively and accurately document research procedures.
Experience and ability to perform standard laboratory techniques. Experience working in a fast-paced research laboratory, ability to prioritize tasks to meet goals, ability to troubleshoot and modify protocols to meet deadlines.
Thorough knowledge of cell culture techniques and maintenance of cell culture facilities.
Proven experience with lipid analysis, mass spectrometry and hands on laboratory techniques.
Ability to learn new techniques including technical aspects of mass spectrometry and related analytical procedures and the application of these techniques to lipid analysis.
Ability to prepare extracted lipids for analysis by gas chromatography (GC) and liquid chromatography coupled with mass spectrometry (LC-MS).
Experience working with chemical, and biological hazards and the ability to recognize safety problems.
Thorough knowledge of basic laboratory procedures and equipment, including preparation of buffers and solutions.
Ability to follow basic research protocols and follow both oral and written instructions closely. Skill in accurate record keeping and ability to organize and calculate.
Ability to utilize multiple types of computer programs for operating scientific equipment, recor
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