The responsibilities include the performance of experiments with different techniques which are summarized as: i) electrophysiological approaches, including extracellular recordings of spinal reflexes utilizing the ex vivo spinal cord preparation, intracellular recordings using whole-cell patch clamp techniques and electromyography (EMG) either in ex vivo or in vivo approaches; ii) modern tracing techniques to decipher maps of neuronal circuits in neonatal spinal cord of mice using viral based techniques; iii) use immunohistochemistry to acquire images using confocal microscopy and quantitate expression levels of various proteins and enzymes in spinal cord sections from mouse models of SMA; iv) conduct behavioral assessment in freely moving mice in vivo to assess the efficacy of various drug treatments in mouse models of SMA; v) train junior members of the Mentis Lab, including perspective PhD rotation students, PhD candidates, interns as well as technicians.
Internal Number: 7621
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