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Cystic fibrosis transmembrane conductance regulator (CFTR) is a cAMP-regulated chloride channel located primarily on the apical surface of epithelial cells that line various organs, including the airways and the gut. CFTR dysfunction is detrimental and may result in life-threatening medical disorders. Dr. Naren's laboratory studies two such disorders; (1) Cystic fibrosis, a lethal genetic disease that affects mostly the Caucasian population (>30,000 in USA), in which the CFTR chloride channel is HYPO-functional and (2) Secretory diarrhea, a disease affecting millions of children worldwide, in which HYPER-function of the CFTR chloride channel can occur due to infectious toxins, such as cholera toxin and E. coli enterotoxin. His lab is interested in identifying interactions between CFTR and its binding partners and defining how spatiotemporal regulation of CFTR-containing macromolecular complexes in the apical compartment of polarized epithelial cells lining the secretory epithelia regulates overall fluid secretion. Our studies will identify new drug targets for cystic fibrosis, secretory diarrhea, and other diseases resulting from CFTR dysfunction and provide insights into the etiology of diseases associated with CFTR-interacting molecules.
The Project Scientist works independently and in cooperation with the Principal Investigator to make significant and creative contributions to a research or creative project in any academic discipline. The Project Scientist may be an ongoing member of a research team or may be employed for a limited period of time to contribute high-level skills to a specific research or creative program. Project Scientists are not required to carry out independent research or to develop an independent research reputation and do not have teaching responsibilities. Ordinarily, the Project Scientist title will carry out research or creative programs as well as administration of day-to-day lab operations with supervision by a member of the Professorial Series.
Primary Duties and Responsibilities:
May assist in preparation of grant proposals, submissions, publications and presentations but is not responsible for generating grant funds.
May serve as PI for certain grants as approved by supervising member of the Professorial Series.
May participate in publications and presentations as author or co-author.
May develop, adapt and implement new research techniques and protocols.
Assists in lab experiments.
Analyzes, interprets, summarizes and compiles data.
May lead or train Staff Research Associates and Research Fellows.
Will assist in day-to-day laboratory activities.
Appointees on an academic trajectory will be expected to commit a portion of their time to developing an independent range of research.
Doctorate degree required. Demonstrated significant, original, and creative contributions to a research or creative program or project.
Experience and Skillset:
Completion of postdoctoral appointment in area of specialization, as applicable.
Knowledge of PI's area of research specialization.
Demonstrated technical competency in a variety of research techniques and protocols.
Working Title: Project Scientist - Cystic Fibrosis
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