The Department of Veterinary Biomedical Sciences invites applications for a full-time 1.00 FTE, 12-month, fixed-term Faculty Research Assistant position. Reappointment is at the discretion of the Department Head.
Our laboratory focuses on enhancement of cellular delivery of antisense oligos, especially Morpholino oligomers (uncharged nucleic acid analogs used as drugs and in biological research to modulate gene expression). We collaborate with an extensive network of international and domestic biologists to test our antisense compounds in various research fields. Pathogens over biological safety level (BSL)-2 are handled by our collaborators, not in our laboratory. Our collaborators test our antisense conjugates in systems including genetic diseases (e.g. cystic fibrosis, muscular dystrophy, spinal muscular atrophy) and viruses (e.g. SARS-CoV-2, influenza, dengue). We also collaborate on projects that include anti-bacterial, ocular and tumor applications.
The Faculty Research Assistant (FRA) will carry out synthesis and purification of antisense oligos conjugated with delivery-enhancing moieties and conduct research on improving bioconjugation chemistry to deliver antisense oligonucleotides into cells. This position is in the Department of Biomedical Sciences, Carlson College of Veterinary Medicine. The lab PI has over 25 years of experience in industry and academia within this research field.
Research opportunities for this position may include: assisting in design of delivery moieties for tissue-specific uptake, developing new conjugation chemistries, scaling up production and determining the pharmacokinetic properties, uptake mechanisms and tissue distribution of drug candidates.
Requires Bachelor's degree in discipline appropriate to the field in which research is being conducted.
B.S. in chemistry (protein & nucleic acid chemistry, organic chemistry, natural products synthesis,), chemical/biomedical engineering, biochemistry or related fields.
Experience in synthesis, purification, and characterization of organic compounds.
Experience in various types of column chromatography.
At least two years of research experience in an academic research, industrial or government laboratory.
Proficiency in both written and spoken English and in MS Office (especially Excel and Word).
Ability to work effectively as a good team player.
Demonstrable commitment to promoting and enhancing diversity.
This position is designated as a critical or security-sensitive position; therefore, the incumbent must successfully complete a criminal history check and be determined to be position qualified as per OSU Standard 576-055-0000 et seq. Incumbents are required to self-report convictions and those in youth programs may have additional criminal history checks every 24 months.
This position will work in a clean and bright chemistry and cell biology laboratory with experienced nucleic acid and peptide chemists, a virologist, and graduate and undergraduate students. A separate chemical laboratory with three fume hoods is available for synthetic work.
Oregon State is a leading research university located in one of the safest, smartest, greenest small cities in the nation. Situated 90 miles south of Portland, and an hour from the Cascades or the Pacific Coast, Corvallis is the perfect home base for exploring Oregon?s natural wonders.Oregon State University has always been a place with a purpose ? making a positive difference in quality of life, natural resources and economic prosperity in Oregon and beyond. Through discovery, innovation and application, we are meeting challenges, solving problems and turning ideas into reality.Founded in 1868, Oregon State is the state?s Land Grant university and is one of only two universities in the U.S. to have Sea Grant, Space Grant and Sun Grant designations. Oregon State is also the only university in Oregon to hold both the Carnegie Foundation's top designation for research institutions and its prestigious Community Engagement classification.As Oregon?s leading public research university, with $261.7 million in external funding in the 2011 fiscal year, Oregon State?s impact reaches across the state and beyond. With 12 colleges, 15 Agricultural Experiment Stations, 35 county Extension offic...es, the Hatfield Marine Sciences Center in Newport and OSU-Cascades in Bend, Oregon State has a presence in every one of Oregon?s 36 counties, with a statewide economic footprint of $2.06 billion.Oregon State welcomes a diverse student body of over 26,000 students from across Oregon, all 50 states and more than 100 countries. They can choose from more than 200 undergraduate and more than 80 graduate degree programs, including over 30 degrees online offered through Oregon State Ecampus. Oregon State increasingly attracts high-achieving students, with nationally recognized programs in areas such as conservation biology, agricultural sciences, nuclear engineering, forestry, fisheries and wildlife management, community health, pharmacy and zoology.Oregon State also ranks high in sustainability, fourth among universities nationwide for using renewable energy and first in the Pac-12 Conference. And our students literally help power the university: 22 exercise machines at Oregon State University has always been a place with a purpose ? making a positive difference in quality of life, natural resources and economic prosperity in Oregon and beyond. Through discovery, innovation and application, we are meeting challenges, solving problems and turning ideas into reality. For more information visithttp://www.ohsu.edu/xd/about/index.cfm.The 400-acre main campus in Corvallis includes a Historic District, making Oregon State one of only a handful of U.S. university campuses listed on the National Register of Historic Places. The district includes such icons as Weatherford Hall, the Memorial Union and Benton Hall, the oldest building on the oldest building on campus.OSU commits to inclusive excellence by advancing equity and diversity in all that we do. We are an Affirmative Action/Equal Opportunity employer, and particularly encourage applications from members of historically underrepresented racial/ethnic groups, women, individuals with disabilities, veterans, LGBTQ community members, and others who demonstrate the ability to help us achieve our vision of a diverse and inclusive community.