Under the general supervision of the Operations Manager, Animal Care Coordinator, Husbandry Supervisor and/or Animal Laboratory Technician III (Lead Technician), our Animal Lab Tech I will be responsible for performing technical, specialized and aseptic procedures in support of the Cedars-Sinai transgenic rodent research models of human disease in the Davis and AHSP facilities. In this role, you will perform Husbandry, housing and care of rodents in Micro Isolator units within Individual Ventilated Cage Rack HEPA systems via Animal Transfer Stations or Biological Safety Cabinets within Biocontainment and Bioexclusion parameters under strict environmental controls. This will include maintaining hazardous agents (biological, chemical, radiation), pathogenic agents and carcinogenic/mutagenic populations post procedural or postsurgical exposure with the use of specific Personal Protective Equipment and specialized operating procedures (SOPs). Will monitor research models for clinical/biological abnormalities, performs daily monitoring/documentation of environmental conditions, and electronic population census with documentation for per diem support and IACUC protocol accountability. You must be a motivated self-starter with high Performance metrics, good Commitment to teamwork practices, and excellent Businesslike and Professional Behavior at all times, including good communication (in English) skills.
Responsible to maintain strict aseptic and micro isolator technique in handling of all rodent animal model populations housed with the AHSP and Davis facility holding rooms and procedural spaces to prevent cross-contamination and protect immunocompromised animal models on a daily basis with adherence to a Day 7 and Day 14 husbandry schedule.
Responsible for feeding and twice daily monitoring of specialized diets to include irradiated, research designated diets, hazardous and chemically fortified feeds. Responsible for monitoring Reverse Osmosis/De-Ionized, 18Megaohm ultra-pure water available at cage level and at Room Distribution Systems. Additionally, provide medicated and antibiotic water exposure and twice daily monitoring and documentation for multiple studies across both facilities.
Responsible for monitoring animal room environments:
Monitoring and ensuring appropriate photo period cycle daily: setting and assessing room mechanical timer for appropriate operation on 24-hour cycle for 14-hour day and 10-hour dark cycle.
Tracking and documenting temperature range every 24 hours within strict tolerances across all holding rooms according to the Guide for the Care and Use of Laboratory Animals standards with minimum and maximum ranges per species.
Tracking and documenting relative humidity (RH) every 24 hours as impacted by ambient environment with attention to the Guide for the Care and Use of Laboratory Animal standards for acceptable ranges per species.
Operating within a noise and vibration monitored environment to protect research models from disruptive confounding and breeding sensitive impact.
Reporting all deviations in animal room environments through Chain of Command.
Provide care for immuno-compromised, transgenic, genetically modified animals with unique and specialized genotypes exhibiting unique phenotypes and requiring varied specialized supportive care. These populations are exposed to and carry adventitious known/unknown pathogens, and/or are designated as biohazardous, BioSafety Level II.
Observe and recognize clinical symptoms of abnormalities in laboratory animals and promptly report abnormalities via Clinical Health Report for update of CM Clinical Case database and Principal Investigator investigation.
Responsible for reading, comprehending, and following a large number of varying Specialized Operating Procedures (SOPs).
Responsible for following written and oral instructions (in English).
Top 25 Murine Procedures. Top 25 Rattus Procedures.
Chemical Biohazardous Rodent 2-Day (CBR2) / Lifetime Biohazard Mouse (LBM) / Lifetime Biohazard Rat (LBR): Procedures related to the numerous hazardous agents in AHSP and Davis facilities used by research labs for model development.
Use of isolation cubicles for containment of lifetime hazard research models.
Use of electronic data capture system for daily barcoding and uploading of identification coded cards for per diem billing, census purposes, and workflow assignment.
Twice weekly receiving of delivered animals: inspect all animals for abnormalities, house in designated facility and holding room. For any observed health abnormalities and deviations from expected quantity, sex, age, weight, strain/stock designation, immediately report data or deviations in criteria via appropriate Chain of Command.
Support research lab rodent breeding programs: identify gravid rodents, monitor to parturition, identify birth dates and forecast weaning dates to protect animal welfare, maintain researcher compliance and support generational research goals.
Supports CM logistics:
Loading of Box Truck transport vehicle.
Transport of animals, materials, equipment between AHSP and Davis facilities.
Maintain Cargo Securement Rules: Appropriate regulations for cargo transport (FMCSA-like guideline).
Appropriate use of cargo tie-down equipment.
Use of cradles for rolling unit security (pallet jacks).
Placed in direct contact with each other.
Prevent from shifting towards each other while in transit.
Performs other duties as assigned or required.
High school Diploma/GED required
Able to read and comprehend written and verbal instructions in English.
Providing healthcare for more than 100 years, Cedars-Sinai has evolved into one of the most dynamic and highly renowned medical centers in the world. Along with caring for patients, Cedars-Sinai is a hub for biomedical research and a training center for future physicians and other healthcare professionals. This attracts exceptional talent to Cedars-Sinai, including world-renowned physician-scientists who seek a place where they can both conduct research and see patients--the ideal formula for discovery and its translation into cures. Our patients benefit from access to doctors at the top of their fields, and our researchers have an ideal community in which to study the impact of healthcare challenges, and reflect that knowledge in their research. The greater Los Angeles area in which Cedars-Sinai resides possesses unparalleled cultural and ethnic diversity which offers outstanding opportunities for translational and clinical research and a dynamic environment for medical education.Although community based, Cedars-Sinai is a major t...eaching hospital affiliated with the David Geffen School of Medicine at the University of California, Los Angeles (UCLA). Cedars-Sinai has highly competitive graduate medical education programs in more than 50 specialty and subspecialty areas, a graduate program in biomedical sciences and translational medicine, a clinical scholars program directed towards junior physicians with aspirations to become clinical scientists, and post graduate training opportunities.There are more than 250 full-time faculty members at Cedars-Sinai. The voluntary medical staff, comprised of more than 2,200 specialty board-certified or board-qualified physicians, represent all of the specialties and subspecialties and collaborate with full-time medical staff in the teaching responsibilities of the graduate medical education programs.