The University of Washington (UW) is proud to be one of the nation’s premier educational and research institutions. Our people are the most important asset in our pursuit of achieving excellence in education, research, and community service. Our staff not only enjoys outstanding benefits and professional growth opportunities, but also an environment noted for diversity, community involvement, intellectual excitement, artistic pursuits, and natural beauty.
At the University of Washington, diversity is integral to excellence. We value and honor diverse experiences and perspectives, strive to create welcoming and respectful learning environments, and promote access, opportunity and justice for all.
The University of Washington, Department of Laboratory Medicine and Pathology is a broad and dynamic department that strives for a consistent level of high achievement in all of its activities. The Department offers full diagnostic services in all areas of Laboratory Medicine and Pathology, is a top ranked research organization as measured by research awards from the National Institutes of Health and offers an array of specialized educational training programs.
The UW Medicine Department of Laboratory Medicine and Pathology brings together state-of-the-art technology and highly trained, world renowned personnel to provide comprehensive diagnostic and personalized service to physicians, community hospitals, independent laboratories, and other health care organizations. Our operations are based at the University of Washington Medical Center, Harborview Medical Center, South Lake Union, Northwest Hospital and the Seattle Cancer Care Alliance. Faculty members also serve at Seattle Children's Hospital, the Veteran’s Administration Puget Sound Healthcare System, and the Fred Hutchinson Cancer Research Center. These collaborative efforts have generated innovative, translational studies in the basic mechanisms of disease as they apply to diagnostic laboratory medicine and pathology.
The UW BioRepository and Integrated Neuropathology (BRaIN) Research Laboratory has an outstanding position for a Temporary (1.0 FTE, Project position (max. 12-months)) Research Scientist.
This is an excellent opportunity for the scientist to participate in a team whose goal is to support human brain research. The Research Scientist 2 will help lead complex procedures associated with research donor brain tissue processing and analytical activities, including histological and antibody-based tissue section staining for evaluation by neuropathologists and neuroscientists. The research scientist 2 will also participate in quantitative tissue based assays, including preparation/protein extractions for these assays, which include protein measurements, and targeted and multiplexed immunoassays to determine molecular changes associated with neurodegeneration, neurotrauma, and dementia. In addition, the research scientist 2 may participate in/provide support for other laboratory projects, which may include tissue clearing and staining for three dimensional microscopic reconstructions of brain injury and disease, in silico 3D reconstructions of microscopic and gross brain images, participation in slide scanning and image analytics, and other tissue analytics. Opportunities to participate in human cell culture projects and work with invertebrate animal model systems may be available. Specimen preparation for and application of molecular analysis of human tissues, cells, and biofluids with respect to RNA and DNA applications including single cell profiling may be available.
The successful applicant will be required to perform special stains via automated stainer and or manual staining; use and maintain laboratory instruments; perform quality control and quality assurance; perform research and assist in development of new procedures; monitor reagent use, and perform preventative maintenance on instruments according to prescribed protocols. The successful applicant will also be expected to participate in lab and other meetings, provide regular progress updates, review work lists and prioritize work in conjunction with the PI and interact with the research team and collaborators. They will independently dissect and assess key anatomical structures (> 90) to isolate for experimental tissue analysis with minimal supervision. They will follow and in some cases develop needed protocols to extract tissue analytes, including but not limited to RNA, DNA, protein, cell types, etc. for tissue and tissue and fluid-based immunoassays. The research scientist 2 will also provide support for in silico 3D reconstructions of gross brain images. The successful applicant will contribute to maintaining updated records and protocols in the lab, and will interface with senior research scientists and the PI, particularly with respect to methods components, for manuscript preparation. Finally, the research scientist 2 will be expected to monitor and direct junior staff to ensure correct procedures are followed and assist with a variety of special projects and research related duties as assigned in a research environment where innovation and novel analytic applications form the foundation of an integrated model of precision neuropathology.
This position has operational access to patient health information and clinical materials including pathology specimens and archival blocks and slides, and for these activities must adhere to the covered entity HIPPA Privacy and CLIA rules and has 'dotted line' reporting to the CLIA certificate holders and applicable clinical laboratory management staff.
Requirements: Minimum education requirement of a Bachelor's Degree with coursework in neuroscience, chemistry, biology, other biological sciences or related field or equivalent combination of education and experience. Two to four years’ experience in a related area or equivalent.
Desired: HT or HTL certified by the American Society of Clinical Pathologist (ASCP) Clinical anatomic laboratory experience OR equivalent education/experience. Experience with any or all of the following: Immunohistochemistry, immunofluorescence staining, protein assays and solution phase immunoassays, molecular applications including tissue and single cell RNA and DNA sequencing, brightfield or fluorescence microscopy, cellular and molecular neuroscience.
Conditions of Employment: UW Research Scientists are essential to BRaIN research laboratory activities; this position occasionally requires work after-hours, weekends and or outside normal business hours.
The application process for UW positions may include completion of a variety of online assessments to obtain additional information that will be used in the evaluation process. These assessments may include Work Authorization, Cover Letter, and/or others. Any assessments that you need to complete will appear on your screen as soon as you select “Apply to this position”. Once you begin an assessment, it must be completed at that time; if you do not complete the assessment you will be prompted to do so the next time you access your “My Jobs” page. If you select to take it later, it will appear on your "My Jobs" page to take when you are ready. Please note that your application will not be reviewed, and you will not be considered for this position until all required assessments have been completed.
Founded in 1861, the University of Washington is one of the oldest public institutions in the west coast and one of the preeminent research universities in the world. The University of Washington is a multi-campus university comprised of three different campuses: Seattle, Tacoma, and Bothell. The Seattle campus is made up of sixteen schools and colleges that serve students ranging from an undergraduate level to a doctoral level. The university is home to world-class libraries, arts, music, drama, and sports, as well as the highest quality medical care in Washington State and a world-class academic medical center. The teaching and research of the University’s many professional schools provide undergraduate and graduate students the education necessary toward achieving an excellence that will serve the state, the region, and the nation. As part of a large and diverse community, the University of Washington serves more students than any other institution in the Northwest.