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Post Doc Instructions:
Please do not submit an application to this posting.� To apply for this postdoctoral research opportunity, follow the directions below in �Applicant Special Instructions�.
Department Name/Job Location:
This position is in the Department of Internal Medicine, Division of Nephrology. This position is for the Medical School Campus.
Acute kidney injury causes high mortality via its secondary organ effects, but there are no specific therapeutic strategies. The postdoctoral fellow will perform studies in the emerging field of “interorgan crosstalk”, using organ injury models in mice. They will use state-of-the-art technologies, such as single cell/single nucleus RNAseq, proteomics, targeted antibodies or drugs, organ transplantation (in collaboration) and transgenic mice.
The Herrlich Lab identified a novel mediator that is released from the injured kidney and causes remote acute lung injury (unpublished data). This work is based on single-cell RNAseq experiments of kidney and lung after acute kidney injury. We are currently using transgenic mice and transplantation experiments of kidney or lung to investigate specific mechanisms involved and to identify target cells of this kidney-released mediator in the lung. In addition, we are focused on examining immune cells involved in remote organ injury and are performing cell fate mapping studies in this context.
Key benefits of this position:
Opportunity to join an important emerging field of science: “Interorgan Crosstalk”.
Existing data on our novel kidney-lung mediator provides strong basis for mechanistic studies.
Existing transgenic mice can be immediately used for mechanistic studies of the novel mediator and its lung receptors and for cell fate mapping studies.
Existing funding for this position is available for up to 3-4 years (but postdoctoral funding applications are encouraged).
In collaboration with the PI, perform studies of interorgan crosstalk in injury models in mice in vivo and in vitro in cell lines.
Analyze and report data to the PI.
Work with mice and oversee their own mouse colony and breeding schemes.
Perform mouse surgeries.
Assist with grant preparation and reporting.
Prepare and submit papers on research.
Assist in the design of research experiments.
Evaluate research findings and assist in the reporting of the results.
Maintain conscientious discharge of their research responsibilities.
Maintain conformity with ethical standards in research.
Maintain compliance with good laboratory practice, including the maintenance of adequate research records
Engage in open and timely discussion with their mentor regarding possession or distribution of material, reagents, or records belonging to their laboratory and any proposed disclosure of findings or techniques privately or in publications.
Maintain collegial conduct towards co-trainees, staff members and members of the research group.
Adhere to all applicable University policies, procedures and regulations. All data, research records and materials and other intellectual property generated in University laboratories remain the property of the University.
Ph.D., M.D. or an equivalent terminal or doctoral degree.
Prior experience with mouse handling and surgeries.
Demonstrated ability to implement laboratory procedures, conduct research and records findings.
Base pay commensurate with experience.
All external candidates receiving an offer for employment will be required to submit to pre-employment screening for this position. Current employees applying for a new position within the university may be subject to this requirement. The screenings will include a criminal background check and, as applicable for the position, other background checks, drug screen, employment and education or licensure/certification verification, physical examination, certain vaccinations and/or governmental registry checks. All offers are contingent upon successful completion of required screening.
This position works in a laboratory environment with potential exposure to biological and chemical hazards. The individual must be physically able to wear protective equipment and to provide standard care to research animals.
Internal Applicant Instruction:
Please attach a copy of your most current signed performance evaluation (completed within the last 18 months) to your online account. If you have not received a performance evaluation, you may provide two current signed letters of recommendation (written within the last 18 months), preferably to include one letter from either a current or recent former supervisor. To attach these documents, go to: My Career Tools, Add Attachment, Attachment Type – Performance Reviews or Letters of Recommendation.
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