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Post Doc Instructions:
Please do not submit an application to this posting.� To apply for this postdoctoral research opportunity, follow the directions below in �Applicant Special Instructions�.
Department Name/Job Location:
This position is in the Department of Genetics. This position is for the Medical School Campus.
Postdoctoral positions to study mitochondrial dysfunction and neurometabolic axon/glia interactions in ALS and other neurodegenerative disorders.
We invite highly motivated candidates to apply for positions as postdoctoral fellows in the laboratory of Dr. Jeff Milbrandt in the Department of Genetics at Washington University in St. Louis. Our primary goal is to unravel the mechanism of axon degeneration and its role in neurodegenerative disease. Many of our projects are pursued collaboratively with the Aaron DiAntonio lab and focus on how defects in NAD homeostasis alter disease progression in peripheral neuropathy, ALS and retinal degenerative disorders. One set of studies is aimed at determining how the NADase activity of the TIR domain protein SARM1 is regulated and how its activity influences downstream signaling pathways that control axon maintenance. Another area of interest focuses on motor neuron abnormalities that occur in ALS and in peripheral neuropathy. In particular, we are interested in the unique metabolic vulnerability of motor axons and how metabolic deficits and mitochondrial dysfunction in Schwann cells contribute to motor neuron diseases. We are also pursuing studies to define the cellular composition of peripheral nerves, particularly the microglial-like cells that contribute to nerve homeostasis as well as disease progression. These projects utilize a wide breadth of technologies from single cell sequencing to mass spectrometry to high throughput, quantitative imaging. In addition, we use human genetics, AAV viral therapies, and disease models, including mutant mice and iPSC-derived neurons to further understand neurodegenerative processes. These projects are funded by multiple grants from the NIH.
Full-time positions are available immediately and are funded for up to three years, with the possibility of extension.
Washington University School of Medicine (WUSM) has a rich history of success in research, education and patient care, earning it a reputation as one of the premier medical schools in the world. The University is internationally known for studies in genetics and neuroscience.
Ph.D. or MD/Ph.D. in biological sciences or related fields.
Experience in molecular biology, neuroscience or genomics.
Good communication skills.
Must be able to visit St. Louis for potential interviews.
Base pay commensurate with experience.
All external candidates receiving an offer for employment will be required to submit to pre-employment screening for this position. Current employees applying for a new position within the university may be subject to this requirement. The screenings will include a criminal background check and, as applicable for the position, other background checks, drug screen, employment and education or licensure/certification verification, physical examination, certain vaccinations and/or governmental registry checks. All offers are contingent upon successful completion of required screening.
To apply for this position, applicants should email a single PDF file consisting of a letter of interest and CV, and should arrange for three letters of reference to be sent to Dr. Jeff Milbrandt at email@example.com.
Internal Applicant Instruction:
Please attach a copy of your most current signed performance evaluation (completed within the last 18 months) to your online account. If you have not received a performance evaluation, you may provide two current signed letters of recommendation (written within the last 18 months), preferably to include one letter from either a current or recent former supervisor. To attach these documents, go to: My Career Tools, Add Attachment, Attachment Type – Performance Reviews or Letters of Recommendation.
Washington University in St. Louis, a medium-sized, independent university, is dedicated to challenging its faculty and students alike to seek new knowledge and greater understanding of an ever-changing, multicultural world. The University offers more than 90 programs and almost 1,500 courses leading to bachelor's, master's and doctoral degrees in a broad spectrum of traditional and interdisciplinary fields, with additional opportunities for minor concentrations and individualized programs. The faculty is composed of scholars, scientists, artists and members of the learned professions. They serve society by teaching; by adding to the store of human art, creativity, understanding, and wisdom; and by providing direct services, such as health care.