The PhD-level Staff Scientist will be part of the Cortez Laboratory in the Department of Biochemistry at Vanderbilt University, and conduct research centered on mechanisms that maintain genome integrity and promote the accurate replication of the genome. The lab utilizes genetics, biochemistry, cell biology, proteomics, and structural biology methods to uncover(1) mechanisms regulatingDNA replication and DNA repairwith an emphasis on novel protein functions; (2) cellular responses to environmental and endogenous genotoxic agents; (3) the activation, regulation,and functions of cell cycle checkpointkinases. Our goal is to understand the differences between pathologicaland physiologicalstates, and identify ways to exploit these differences for the treatment of cancer.
The ideal candidate should have a PhD in a relevant scientific discipline and a record of productive research experience related to genome maintenance, DNA replication, or DNA repair. Specific responsibilities and qualifications are outlined below.
The Cortez Lab isan interactive and highly collaborative group, with access to outstanding instrumentation,core facilities, and colleagues.As part of the Genome Maintenance Program in the Vanderbilt-Ingram Cancer Centerand Department of Biochemistry, the lab benefitsfrom interactions with over 25 additional laboratories studying similar topics.The diverse expertiseof these investigatorscombinedwith extensive career development services and benefits,make itan excellent environmentfor both research and training.
Duties and Responsibilities
Conduct independent research:
Design and execute experiments with minimalsupervision
Interpret data, generate hypotheses,and implement a research plan
Manage multiple taskssimultaneously
Communicate research discoveries:
Analyze data to communicate results and their implications ina clear fashion
Draft and edit research papers for publication
Assist in obtaining grant funding to support research activities
Engagewith and train labmembers:
Work collaboratively with other labmembers andcolleagues
Assist labmembers in developing ideas, techniques,and protocols
Communicate with other labmembers to share results and plan complex experiments
This position may require the scientist to participate in the training of students, postdocs, and other staff. The position reports administratively and functionally to the PI.
A PhD or equivalent degreeis necessary.
Aminimum of 2 years postdoctoral experienceis necessary.
Research experience in DNA replication, DNA repair,or a closely related fieldis necessary.
Experience with mammalian cell culture and molecular biology techniques (DNA cloning, PCR, gel electrophoresis, molecular hybridization, etc.) is necessary.
Experience with RNA interference, CRISPR-based technologies, microscopy, protein expression and purification is preferred.
Experience with analysis of large datasets including RNAseq, NGS, and ChIP data is preferred.
Experience with mining published cancer genomics datasets is preferred.
Ability to independently design, organize, and execute scientific research projects is essential.
Ability to collect, test, and evaluate data/results is necessary.
Must be able to effectively communicate research discoveries through oral presentations and draftmanuscripts based on original research.
A strong record of research productivity isnecessary.
Proficiency in statistical analyses, Prism, Adobe Illustrator, and Microsoft Excel is strongly preferred.
Ability to exerciseindependent judgement to develop concepts and new approaches for research is preferred.
Must be an effective team player with an ability to perform in a rigorous and organized manner, have excellent interpersonal and analytical skills, and a strong work ethic.
Commitment to Equity, Diversity, and Inclusion
At Vanderbilt University, we are intentional about and assume accountability for fostering advancement and respect for equity, diversity, and inclusion for all students, faculty, and staff. Our commitment to diversity makes us who we are. We have created a community that celebrates differences and lets individuality thrive. As part of this commitment, we actively value diversity in our workplace and learning environments as we seek to take advantage of the rich backgrounds and abilities of everyone. The diverse voices of Vanderbilt represent an invaluable resource for the University in its efforts to fulfill its mission and strive to be an example of excellence in higher education.
Vanderbilt University is an equal opportunity, affirmative action employer. Women, minorities, people with disabilities and protected veterans are encouraged to apply.
Please note, all candidates selected for an offer of employment are subject to pre-employment background checks, which may include but are not limited to, based on the role for which they have been selected: criminal history, education verification, social media review, motor vehicle records, credit history, and professional license verification.
Internal Number: 10000180
About Vanderbilt University
Vanderbilt University is a center for scholarly research, informed and creative teaching, and service to the community and society at large. Vanderbilt will uphold the highest standards and be a leader in the quest for new knowledge through scholarship, the dissemination of knowledge through teaching and outreach, and the creative experimentation of ideas and concepts. In pursuit of these goals, Vanderbilt values most highly intellectual freedom that supports open inquiry, equality, compassion, and excellence in all endeavors.