Dr. Keith Syson Chan's laboratory is seeking a postdoctoral scientist to conduct studies to characterize a newly-discovered metastatic niche and its modulation of lung colonization, building on existing preliminary studies (RNA seq profiling of tumor and niche cells), tools and established metastatic models. The postdoctoral scientist will also investigate cancer stem cells and their interaction of the immune and stromal microenvironments.

Examples of the significant contributions in the field made by Dr. Chan's lab are found in the following publications:

• https://www.nature.com/articles/nature14034

• https://academic.oup.com/jnci/article/110/5/448/4804352

• http://clincancerres.aacrjournals.org/content/22/4/802

The postdoctoral scientist will work independently but in close cooperation and in consultation with the Principal Investigator and other Research Scientists. The postdoctoral scientist will perform routine and complex laboratory procedures throughout training period and may develop, adapt, and implement new research techniques and protocols. The postdoctoral scientist will be responsible for designing experiments, and assembeling data. He/she will analyze and interpret data, assist in preparation of grant proposals, and participate in publications and presentations as author or co-author. For eager postdoctoral scientists interested in applying for grant funding, mentorship will be provided, but there is no requirement for generating grant funding in this position.

Primary Duties and Responsibilities:

• List the primary duties and responsibilities in order of most significance.
• May assist in preparation of grant proposals, but is not responsible for generating grant funds.
• Responsible for the designe of experiments in cooperation with the mentor.
• Responsible for compiling figures and text for the submission of publications and presentations as author or co-author.
• Designs and performs experiments. Will keep appropriate experimental records and documentation and analyze the results with the mentor.
• May develop, adapt, and implement new research techniques and protocols.
• Operates and maintains equipment and instruments.

Department and/or Unit Specific - Essential Job Responsibilities:

• Characterizes a newly-discovered metastatic niche and its modulation of lung colonization.
• Builds on existing preliminary studies (RNA seq profiling of tumor and niche cells), tools and established metastatic models.
• Investigates cancer stem cells and their interaction of the immune and stromal microenvironments.
• Investigates the immune microenvironment in modulating bladder cancer progression and therapeutic response.