A cover letter is required for consideration for this position and should be attached as the first page of your resume. The cover letter should address your specific interest in the position and outline skills and experience that directly relate to this position.
The Center for Structural Biology (CSB) within the Life Sciences Institute is looking for an experienced crystallographer to advance the research objectives of principal investigators in a wide variety of basic science fields and drug development. The CSB includes: a high-throughput cloning and expression laboratory for protein engineering; protein expression and purification facilities for small- and large-scale protein production; macromolecular crystallization and crystallography laboratories for solving crystal structures of biological molecules; and x-ray facilities with membership access to high energy synchotron radiation (LS-CAT beam-lines at the Argonne National Laboratory). Staff scientists in the CSB work under the direction of the Managing Director, Dr. Jeanne A. Stuckey, and will work in collaboration with members of her lab and researchers who use the facilities.
Our mission at the Life Sciences Institute is to advance the understanding of the fundamental processes of life, and to pioneer new ideas to improve human health.
For additional information on the Life Sciences Institute, please go to: https://www.lsi.umich.edu/about.
For additional information on the CSB:, please go to: https://www.lsi.umich.edu/science/centers-technologies/center-structural-biology
Experimental responsibilities will include:
Design and execute experiments in collaboration with others
Help coordinate and manage projects
Perform quantitative analyses and communicate findings through reports and summaries
Perform innovative research resulting in co- and lead-authored publications on structures of therapeutic and biological importance
Facilitate the utilization of protein structures by providing expert interpretation to enhance the design efforts of the medicinal and computational chemists
Execute your grasp of modern cloning, expression and purification methodologies
Develop novel crystallization techniques
Perform crystallization screens
Non-experimental responsibilities will include:
Maintain clear laboratory notebooks
Provide detailed documentation so experiments can be replicated
Follow laboratory best practices for safety and quality
Ph.D. in structural biology, biophysics, biochemistry or related discipline
Minimum of 1 year post-doctoral work experience
Minimum of 3 years crystallography experience in construct design, structure determination and interpretation
Prior experience working in a collaborative environment
Minimum of 1 year experience in biophysical techniques that assess direct protein-ligand binding (e.g., isothermal calorimetry, mass spectrometry, bio-layer interferometry, fluorescence polarization, NMR)
Minimum of 1 year experience in molecular dynamics simulations
Minimum of 1 year experience in ligand design or modeling
Benefits at the University of Michigan
In addition to a career filled with purpose and opportunity, The University of Michigan offers a comprehensive benefits package to help you stay well, protect yourself and your family and plan for a secure future. Benefits include:
Generous time off
A retirement plan that provides two-for-one matching contributions
Many choices for comprehensive health insurance
Dental, Vision and Legal Insurance
Long-term disability coverage
Flexible spending accounts for healthcare and dependent care expenses
The University of Michigan conducts background checks on all job candidates upon acceptance of a contingent offer and may use a third party administrator to conduct background checks. Background checks are performed in compliance with the Fair Credit Reporting Act.
Job openings are posted for a minimum of seven calendar days. The review and selection process may begin as early as the eighth day after posting. This opening may be removed from posting boards and filled anytime after the minimum posting period has ended.
The University of Michigan is an equal opportunity/affirmative action employer.
Internal Number: 194182
About University of Michigan - Ann Arbor
A great university is made so by its faculty and staff, and Michigan is recognized as one of the best universities to work for in the country. The Michigan culture is known for engaging faculty and staff in all facets of the university to create a workplace that is vibrant and stimulating.For two consecutive years, the Chronicle of Higher Education has placed U-M in its "Great Colleges to Work For" survey. In particular, the university earns high marks for strong relations between faculty and administrators, a collaborative system of governance, strong pay and benefits, and a healthy work/life balance.