The Senior Staff Associate I, in the High-Throughput Screening Facility within the Judith P. Sulzberger Genome Center at the Columbia University Medical Center, will primarily be responsible for the execution of PLATESeq experiments within the lab. PLATESeq is the lab's automated barcoding and pooling Next Gen Sequencing technology, which we used to profile small molecule activity. The candidate will also assist in performing High-Throughput Screening Assays, utilizing laboratory automation. Currently, the center features three automation pieces: the Cell::Explorer (Perkin Elmer), HighRes Bio, and a LabCyte Echo. In addition to the execution of assays the candidate will also perform routine quality assurance protocols to monitor lab automation performance and prevent systematic errors in our automated processes. Responsibilities also include but not limited to tracking consumable inventory, training users on basic instrument controls, and scheduling instrument usage between users/assays.
Duties: - Responsible for carrying out fully planned experiments utilizing laboratory automation (55%). - Preparing solutions and performing other related duties necessary to the functioning of the research project (20%). - Keeping records of experiment results (10%). - Running quality control experiments to insure instrumentation is in proper working order (10%). - Additional duties as requested (5%).
Functional Knowledge: - Basics of automated liquid handling, experimental design and implementation - Basics of High Throughput Screening and Next Generation Sequencing - Has level of expertise about the research subject across multiple functions; considered specialist for multiple functions
Problem Solving: - Solves a broad range of complex problems especially issues with automation - Resolving issues with high throughput data - Exercises judgment based on the analysis of multiple sources of information
Decision Making/Autonomy: - The position requires the ability to execute automation independently, including design and troubleshooting of protocol.
- The position requires independent judgement in regards to the design of automated protocols
- Works independently while working in a collaborative research environment
Leadership: - In consultation with the Director of HTS Core, able to recommend and implement improvements to processes. - Provides guidance to junior team members
Technical Expertise: - Automation and automated liquid handlers - Basic knowledge of informatics - Bench top skills (i.e., pipetting and small instrumentation) - Comprehensive understanding of research techniques, tools, software and instruments used in project. - Assist Director in developing protocols, design instruments, develop applications in support of the project, as needed.
Communication Skills: - Ability to effectively communicate with collaborators and organize schedules. - Explains complex information; collaborates with others to build consensus.
Internal Number: 7069
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