As a Project Scientist in the Department of Pathology, you will work independently and in cooperation with the Principal Investigator to make significant and creative contributions to an assigned research project. The research projects assigned are developed under the direction and in collaboration with the Principal Investigator, Warren Tourtellotte, MD, PhD, Professor and Vice-Chair of Pathology and Laboratory Medicine and Professor of Neurology, Neurosurgery and Biomedical Sciences. You will be expected to have substantial scientific independence, organization, creativity and motivation. A significant track-record of scholarly productivity and strong evidence of successful independent experimental design and execution is expected and essential. This role will include studying the role of microglia in Alzheimer's Disease pathogenesis and evaluating molecules that can modulate microglial function and neurotoxic beta-amyloid processing and homeostasis in the brain. Depending on the candidate's expertise, projects related to development and degeneration of the peripheral nervous system are available. The candidate will be expected to independently design and conduct experiments, collect and analyze data, troubleshoot experimental protocols, consolidate data for publication and grant applications, present research at national and international meetings, and prepare manuscripts for publication. Teaching and supervising other research staff, students, and residents may be required.
PhD (preferably with expertise in neuroscience, neurobiology, molecular biology or a closely related field) is required
Must have a minimum of 2 years of experience as a scientifically productive post-doctoral fellow.
Must have experience with translational research using animal models to study mechanisms of gene function and disease pathogenesis.
Experience in molecular biology, cell culture, immunocytochemistry, Western blotting, PCR, quantitative real-time PCR and histology/imaging techniques including quantitative bright-field and fluorescence microscopy and confocal microscopy is required.
Experience with proteomics analysis of isolated protein complexes will be beneficial for some of the planned protein-protein interaction experiments.
Working Title: Project Scientist - Department of Pathology - Tourtellotte Lab
Providing healthcare for more than 100 years, Cedars-Sinai has evolved into one of the most dynamic and highly renowned medical centers in the world. Along with caring for patients, Cedars-Sinai is a hub for biomedical research and a training center for future physicians and other healthcare professionals. This attracts exceptional talent to Cedars-Sinai, including world-renowned physician-scientists who seek a place where they can both conduct research and see patients--the ideal formula for discovery and its translation into cures. Our patients benefit from access to doctors at the top of their fields, and our researchers have an ideal community in which to study the impact of healthcare challenges, and reflect that knowledge in their research. The greater Los Angeles area in which Cedars-Sinai resides possesses unparalleled cultural and ethnic diversity which offers outstanding opportunities for translational and clinical research and a dynamic environment for medical education.Although community based, Cedars-Sinai is a major t...eaching hospital affiliated with the David Geffen School of Medicine at the University of California, Los Angeles (UCLA). Cedars-Sinai has highly competitive graduate medical education programs in more than 50 specialty and subspecialty areas, a graduate program in biomedical sciences and translational medicine, a clinical scholars program directed towards junior physicians with aspirations to become clinical scientists, and post graduate training opportunities.There are more than 250 full-time faculty members at Cedars-Sinai. The voluntary medical staff, comprised of more than 2,200 specialty board-certified or board-qualified physicians, represent all of the specialties and subspecialties and collaborate with full-time medical staff in the teaching responsibilities of the graduate medical education programs.