Send or email CV, brief statement of research and names/contact details of three references to Andrzej A. Dlugosz, MD; c/o L VanGoor (Lvangoor@umich.edu) University of Michigan Department of Dermatology, 1500 E. Medical Center Dr. SPC5314, Ann Arbor MI 48109,
The University of Michigan Department of Dermatology invites applications for a full-time faculty position at the level of Assistant Research Scientist in our Skin Cancer Biology Research Program. We seek a highly innovative and motivated investigator with extensive postgraduate training in molecular biology, genetics, and signal transduction, and a record of substantial achievement developing and utilizing genetically engineered mouse models to gain fundamental insights into disease, particularly cancer and pre-cancer. This individual will play a pivotal role in team science investigations aimed at advancing our understanding of the molecular, cellular, and tissue basis of Merkel cell carcinoma; in developing and characterizing novel, highly tractable mouse models of this aggressive malignancy; and in utilizing these models for preclinical studies aimed at identifying improved approaches to treatment.
The successful candidate will pursue comprehensive screening studies testing combinations of oncogenes and cell fate determinants as drivers of Merkel cell carcinoma development in transgenic mouse embryos in vivo. These studies will be followed by development of mice carrying inducible forms of these genes and gene combinations, for testing their sufficiency at driving tumorigenesis in adult mice. This work, performed in close collaboration with Dr. Andrzej Dlugosz and Dr. Monique Verhaegen, will serve as a foundation for future studies. Duties will include authoring publications in peer-reviewed scientific journals, assisting with preparation of grant submissions, and formally presenting research findings at relevant national meetings. Good departmental and laboratory citizenship and collegiality are expected, with participation in departmental committees and/or university service.
Applicants must possess a Ph.D. and relevant postgraduate training with extensive experience in a variety of basic laboratory techniques including protein and RNA analysis. In addition to outstanding general lab skills, applicants should have at least 5 years of experience and publications establishing proficiency in the design, development, and characterization of genetically engineered mouse models of human cancer or pre-cancer. This includes tissue collection and detailed characterization using a variety of approaches, including immunostaining, PAGE and immunoblotting, RNA isolation and RT-qPCR, and establishment of cell lines and subcutaneous grafting. Experience generating both conventional and conditional mouse models is required, including both Cre-inducible and doxycycline-regulated systems. In addition, hands-on experience using IRES-elements and 2A linker strategies to co-express multiple cDNAs is highly desirable, as is utilization of the ROSA26 locus for “safe harbor” integration of single-copy transgenes into the mouse genome. Applicants should have a strong commitment to team science, reflected in multi-lab collaborations and publications, along with outstanding communication skills and attention to detail.
The University of Michigan offers an exceptional array of benefits. Salary is competitive and will be commensurate with experience. The University of Michigan provides a world class venue for interdisciplinary collaboration, with broad ranging resources to assist professional growth and development. Known for exceptional schools, sports, restaurants and a lively arts culture, Ann Arbor is consistently rated as one of the best places to live.
Michigan Medicine seeks to recruit and retain a diverse workforce as a reflection of our commitment to serve the diverse people of Michigan and to maintain the excellence of the University. We welcome applications from anyone who would bring additional dimensions to the University’s research, teaching, and clinical mission, including women, members of minority groups, protected veterans, and individuals with disabilities. The Department of Dermatology is committed to a policy of nondiscrimination and equal opportunity for all persons and will not discriminate against any individual because of race, color, national origin, age, marital status, sex, sexual orientation, gender identity, gender expression, disability, religion, height, weight, or veteran status, except as allowed by the need for bona fide occupational qualifications. Reasonable accommodation will also be provided to persons with disabilities, to disabled veterans, and to accommodate religious practice.
Michigan Medicine conducts background screening and pre-employment drug testing on job candidates upon acceptance of a contingent job offer and may use a third party administrator to conduct background screenings. Background screenings are performed in compliance with the Fair Credit Report Act. Pre-employment drug testing applies to all selected candidates, including new or additional faculty and staff appointments, as well as transfers from other U-M campuses.
The University of Michigan is an equal opportunity/affirmative action employer.
Internal Number: 193026
About University of Michigan - Ann Arbor
A great university is made so by its faculty and staff, and Michigan is recognized as one of the best universities to work for in the country. The Michigan culture is known for engaging faculty and staff in all facets of the university to create a workplace that is vibrant and stimulating.For two consecutive years, the Chronicle of Higher Education has placed U-M in its "Great Colleges to Work For" survey. In particular, the university earns high marks for strong relations between faculty and administrators, a collaborative system of governance, strong pay and benefits, and a healthy work/life balance.