Research - Laboratory/Non-Laboratory, Staff/Administrative
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The Division of Medical Genetics currently has an opportunity for a Research Scientist 2 to work on the generation and large-scale production of gene therapy vectors in the Lieber lab. The lab is developing a new form of simplified gene therapy for a variety of diseases to be employed in resource-poor countries. The translation research projects are funded by the NIH, the Bill and Melinda Gates Foundation, and industry.
A central component of the new gene therapy approach are helper-dependent adenovirus vectors, the generation of which is labor- and time-intensive. It requires 100% accuracy, motivation, and the willingness to work during evenings and weekends. The work will mostly involve large-scale cell culture and virus vector production. After a period of training, it is expected that the Research Scientist can simultaneously handle the production of multiple vectors at different stages of development. The Research Scientist will also establish and manage a virus vector repository. This position is a critical member of the lab who will work with the PI and experienced post-docs and industry scientist and help train others.
Perform quality control checks and maintain data for tissue culture, liquid nitrogen, liquid handling robots and sequencing equipment.
Make solutions and reagents for nucleic acid extractions, tissue culture maintenance, model organism growth plates/media and PCR purification.
Perform experiments relate to gene therapy research independently and collaboratively with other lab members.
Develop extensions of existing methods and protocols.
Establish and manage a virus vector repository.
Adapt quickly change direction and priorities based on a rapidly evolving research program.
Participate in laboratory meetings.
Perform related duties as required.
As a UW employee, you will enjoy generous benefits and work/life programs. For detailed information on Benefits for this position, click here.
Bachelor’s degree in biology or other similar fields plus two or more years of experience in research laboratory.
Demonstrated knowledge in molecular and cellular biology
Ability to work flexible hours, including evening and weekend as needed
Ability to work, collaborate and communicate well will with a multidisciplinary team
Strong organizational abilities with a keen ability to work to achieve deadlines and specified milestones.
Equivalent education/experience will substitute for all minimum qualifications except when there are legal requirements, such as a license/certification/registration.
Master’s degree in biology or other similar fields
Experience in complex cloning, cell transfection, quantitative PCR, and large-scale cell culture.
CONDITIONS OF EMPLOYMENT
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