Research - Laboratory/Non-Laboratory, Staff/Administrative
Postdoctoral Researcher - Neurosciences
University of California San Diego
Description A position is open for a postdoctoral researcher with a strong background in neuroscience to join the research laboratory of Dr. Robert Rissman, Associate Professor of Neurosciences, University of California San Diego (UCSD). Applicants should hold (or soon receive) a Ph.D. in neuroscience or a related discipline. The research project will study the role of novel therapeutic strategies and biomarkers for Alzheimer's disease (AD). The position is available January 1, 2021, and located in La Jolla, California.
Research Description Major goals and objectives: to study the role of -syn as a mediator of the toxicity of A to selected neuronal populations in AD; investigate interactions with Rabs and ESCRTIII proteins, -syn aggregates interfere with neuronal endosomal transport of neurotrophic factors (NTFs) leading to selective neuronal damage; study the role of -syn as mediator of the selective neuronal loss in AD by interfering with Rabs and ESCRTIII leading to defective transport of NTFs; assess if brain-penetrating nucleotides targeting -syn might reverse the endosomal alterations and protect selected networks from degenerating in AD. Research Activity
Immunohistochemistry and microscopy studies on brain and other tissues.
Behavioral assays and motivated behavior
Work with genetically modified mice
Live-cell imaging of neuronal/immune cell physiology
Isolate and run biochemical experiments on protein & RNA isolated from mouse tissues
Perform pharmacological manipulations in vivo
Prepare and write manuscripts for publication
Requirements Applicants should hold (or soon receive) a Ph.D. in Neuroscience or a related discipline. Experience with rodent behavioral testing is preferred but not required. Successful applicants should be highly self-motivated, have outstanding experimental skills and be able to think independently but also work well in a team. One first author publication from previous research work is required to be eligible. Document Requirements
Curriculum Vitae - Your most recently updated CV
2-4 letters of reference
First author publication
About Dr. Robert Rissman is an Associate Professor of Neurosciences at the University of California San Diego (UCSD), conducting research in his laboratory on the UCSD School of medicine campus in La Jolla, CA. Dr. Rissman is also the Director of Neuropathology and Biomarker Cores of UCSD's Alzheimer's Disease Research Center (ADRC), a founding Director of the Alzheimer's Disease Cooperative Study (ADCS) Biomarker Core, and has a joint appointment as a Research Biologist at the Veteran's Administration San Diego. UCSD's Department of Neurosciences has a rich, internationally acclaimed history for its contribution to the research of neurodegenerative diseases, particularly AD. Research studies of AD and other neurodegenerative disorders at UC San Diego are part of the clinical bench strength of the UC System. For the past 30 years, UC San Diego has been a leader in AD research and home to the prestigious Shiley-Marcos Alzheimer's Disease Research Center (ADRC) and the Alzheimer's Disease Cooperative Study (ADCS).
The focus of Dr. Rissman's basic science research is novel biomarker discovery studies in experimental neuropathology, focused primarily on Alzheimer's disease (AD). A major focus of his lab in AD biomarkers is studying the utility and mechanistic underpinnings of neuronal exosomes. Dr. Rissman and his research group have published manuscripts demonstrating the ability of tau and a-beta in neuronal exosomes to predict conversion from mild cognitive impairment (MCI) to AD. Dr. Rissman also investigates the contribution of stress and changes in stress signaling intermediates in AD neuropathology. Using transgenic animal models and in vivo pharmacology, experiments focus on identifying the role of corticotropin-releasing factor (CRF) receptors in beta-amyloid deposition, tau phosphorylation, behavioral, and synaptic changes. Dr. Rissman examines postmortem human tissues to assay the specific changes that occur in the CRF signaling system during aging and Alzheimer's disease.
All qualified applicants will receive consideration for employment without regard to race, color, religion, sex, sexual orientation, gender identity, national origin, disability, or status as a protected veteran.
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