The Department of Ophthalmology is seeking a Research Associate who will work in one of our experimental genetics laboratories at Columbia University with duties at the Manhattanville campus. The laboratory focuses on the genetics, pathophysiology, and neurobiology of glaucoma. Glaucoma is a common ocular disease involving harmfully high pressure inside the eye and neural degeneration in the optic nerve and retina. We are looking for an enthusiastic and dedicated candidate with proven meticulous laboratory habits who is able to work independently.
Responsibilities include mapping/identification of new disease genes, molecular techniques to study disease mechanisms, clinical assessment of disease phenotypes, physiologic measurements, and maintenance of mouse colonies.
Ocular phenotype assays of mice including but not limited to: intraocular pressure measurement, outflow capacity measurements, anterior chamber examination, retinal photography, electrophysiology, electroretinography, and optical coherence tomography.
Use techniques to modify intraocular pressure.
Potential development of live imaging and organ culture platforms with automated physiological assessments.
Characterize physiologic and disease mechanisms through mouse mutants and mouse genetics/genotyping.
Image acquisition, processing, and analysis using Image J or other common imaging software.
Perform tests, experiments, and/or procedures following training and detailed protocols.
Close communication with supervising research scientists, post-doctoral scientists, and graduate students regarding mouse phenotyping.
Depending on experience, abilities, and interest there is the possibility of additional specific projects.
Bachelor's degree and 3-5 years of related experience or equivalent in education, training and experience.
Ability to work flexible shifts, which may include occasional weekend work.
Ability to interact in a professional, positive manner to advance the goals of the research program.
Master's Degree and one year of related experience
The ideal candidate will have education in biology and/or physiology.
Experience with physiology, handling mice, and genetics, is desirable but not required.
Equal Opportunity Employer / Disability / Veteran
Columbia University is committed to the hiring of qualified local residents.
Internal Number: 512205
About Columbia University
Columbia University is one of the world's most important centers of research and at the same time a distinctive and distinguished learning environment for undergraduates and graduate students in many scholarly and professional fields. The University recognizes the importance of its location in New York City and seeks to link its research and teaching to the vast resources of a great metropolis. It seeks to attract a diverse and international faculty and student body, to support research and teaching on global issues, and to create academic relationships with many countries and regions. It expects all areas of the university to advance knowledge and learning at the highest level and to convey the products of its efforts to the world.