We are seeking a highly motivated Postdoctoral Research Scientist for Dr. Nakagawa's laboratory at the Herbert Irving Comprehensive Cancer Center. The PDSR will work under the direct guidance of Dr. Nakagawa. The successful applicant will play a key role in preclinical projects related to murine and patient-derived three-dimensional (3D) organoids, representing normal, preneoplastic and cancer oral and esophageal lesions. Characterization of 3D organoids involve basic and advanced cell culture skills (monolayer and 3D), live cell imaging, and pharmacological and genetic manipulations (transient/stable transfection, adenoviral Cre, and lentiviral Crispr/Cas9 system). Prior experience in breeding and handling small animal (genetically engineered mice and immunodeficient mice), tissue dissection, xenograft tumor transplantation and murine tail-vein injection assays are highly desired. Experience with morphology (immunohistochemistry), basic molecular biology (DNA/RNA analyses), cell biology (e.g. flow cytometry, cell proliferation, cell migration/invasion assays) is desired. The successful applicant will have experience in preclinical oncology or related areas, excellent oral and written communication skills, the ability to work independently, and the ability to work in a highly collaborative setting with biologists and clinicians.
Internal Number: 6599
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