The Research Assistant will work with a team of researchers at the Taub Institute for Research on Alzheimer's Disease and the Aging Brain. The selected candidate will participate in an NIH-funded research project focus on biomarker discovery and development. This is a 1-year grant-funded position, with the opportunity of appointment extension.
Executing experiments following protocols and achieving repeatable results (excellent hands-on lab and pipetting skills).
Compiling and maintaining accurate research records, and presenting data in group settings.
Building their scientific knowledge by reading relevant articles and attending seminars.
Demonstrating initiative in solving problems and implementing laboratory procedures.
Organizing time and planning specifics of project related work with oversight from supervisor.
Collaborating with faculty and senior lab members in the performance and analysis of experiments.
Coordinating pick-up and delivery of bio-specimens among laboratories.
Keeping records of samples received, used, and sent out to other laboratories.
Working under sterile contained conditions for processing of human bio-specimens, including blood, Cerebrospinal fluid, and tissue.
Performing Western blots, protein quantification (BCA, Bradford) assays, Immunoprecipitations assays, among other techniques.
Running of biomarker assays (e.g., ELISA, MSD, Simoa, etc.).
Developing, optimizing, validating and troubleshooting of new biomarker assays under the supervision and guidance of the Principal Investigator.
Willing to learn new techniques to achieve the overall goal of the project.
Working with mice occasionally.
Responsible for maintaining laboratory supplies, preparing solutions, and performing other related duties necessary to the well-functioning of the laboratory.
Bachelor's degree and at least one and one-half years of related experience or equivalent in education, training and experience.
Knowledge of various related laboratory procedures and techniques required.
Experience as a full-time Research Assistant in an industrial/academic setting.
Desired prior experience includes ELISA development and optimization, assay protocol optimization and validation (or similar technique).
Experience in the following areas is a plus: conjugation chemistry, e.g. conjugating antibodies to solid surfaces (microbeads), biotinylation, process improvement techniques.
Experience in blood, Cerebrospinal fluid, and tissue processing are preferred.
Exhibit initiative, work independently, and be technically proficient in the processes assigned to them.
Excellent organizational skills, proven ability to effectively plan and organize work activities to meet schedules and deadlines.
Good organizational and record keeping skills.
Familiarity with spreadsheets and/or database software, including Excel and SPPS.
Experience with statistical analysis and experimental design.
Experience working and maintaining a fully functional wet lab, including proficiency in the techniques of PCR, Western Blotting, gel electrophoresis and immunohistochemistry.
Experience with light microscopy and cell culture techniques (primary neuronal cultures and immortalized cell lines) preferred.
Basic skills required include data entry, and knowledge in biology and/or biochemistry.
Good hands, organizational skills, and a keen eye for detail are essential.
Equal Opportunity Employer / Disability / Veteran
Columbia University is committed to the hiring of qualified local residents.
Internal Number: 512058
About Columbia University
Columbia University is one of the world's most important centers of research and at the same time a distinctive and distinguished learning environment for undergraduates and graduate students in many scholarly and professional fields. The University recognizes the importance of its location in New York City and seeks to link its research and teaching to the vast resources of a great metropolis. It seeks to attract a diverse and international faculty and student body, to support research and teaching on global issues, and to create academic relationships with many countries and regions. It expects all areas of the university to advance knowledge and learning at the highest level and to convey the products of its efforts to the world.