This Center is a focal point of a growing Initiative at CUIMC and HICCC that aims to integrate pre-clinical and clinical research towards the development of new mechanism-based, biomarker driven therapeutics and to bring these advances into clinical care and clinical trials. The program will include clinical, laboratory and computational researchers both within CUIMC and HICC and those working across other aspects of CU. The Center will include a clinical component with innovative, model-based methodologies that will be adopted and implemented for rapid translation to the clinic. This clinical aspect will be complemented with a research mission which will span pre-clinical development of therapeutic strategies and pre-clinical testing of emerging therapies in model systems to deep molecular and genomic characterization of samples, including patient samples from innovative clinical trials. One goal is to develop a quantitative framework for the effective and seamless integration of emergent genomic and cancer systems biology driven methodologies and mainstream approaches—including those leveraging oncogene addition, DNA damage repair, and immuno-oncology —for the rational prioritization of optimal, patient-specific treatment options. This goal will be integrated with development of techniques for deep study preclinical and clinical samples to facilitate both pre-clinical and correlative research and develop novel hypotheses based upon samples from clinical trials.
Role: The Laboratory Director will provide scientific and administrative support both for the development of new scientific infrastructure and capabilities for the Center in collaboration with additional investigators and Shared Resources within HICCC and will also play a lead role in the management of the Independent laboratory research of the Center Director. It is estimated that 40% of the effort would be devoted to management of the Director's Laboratory and 60% effort will be devoted to Center Activities. Within the Center, this individual will provide work with the Director, other faculty within the Center and other investigators and Core Directors at HICCC/CUIMC to develop and implement new tools and infrastructure to support and enhance pre-clinical research. This individual will also work in collaboration with computational biologists to develop capacity for analysis of data related to these new tools. Areas to be established include workflows for multi-omic analysis of samples, development of workflows and tools for preclinical testing of therapeutics in model systems and development of workflows for functional genomic experiments. The Laboratory director will facilitate development of these capabilities and development of parallel approaches to study pre-clinical and clinical samples in order to speed both discovery science and translational/correlative research aiming to enhance basic, translational and clinical research programs on cancer therapeutics.
This position reports to the Center Director. Together with the Precision Oncology Steering Committee members, this position promotes synergy and integration of laboratory-based, translational, and clinical research under this initiative.
Manage the day-to-day operations of the CCPM Director's Laboratory including training of new staff, supervision of ordering/inventory of reagents, compliance with preparing documents for regulations and key protocols for animal and human subjects, and assistance with grants management staff on budgeting.
Responsible for working with HICCC Resources and Center faculty to developing and managing infrastructure to facilitate pre-clinical testing of cancer therapeutics in model systems.
Responsible collaborating with Clinical Research Staff and relevant investigators to establish workflows to utilize patient samples for research molecular/genomic studies on patient samples
Responsible for monitoring core metrics regarding use of research researches within the center and helping to establish budgets and methods to recover costs for program services
Responsible for guiding Center Faculty and trainees in the use of Center resources and for integrating these resources into grants and applications for funding.
Internal Number: 6598
About Columbia University
Columbia University is one of the world's most important centers of research and at the same time a distinctive and distinguished learning environment for undergraduates and graduate students in many scholarly and professional fields. The University recognizes the importance of its location in New York City and seeks to link its research and teaching to the vast resources of a great metropolis. It seeks to attract a diverse and international faculty and student body, to support research and teaching on global issues, and to create academic relationships with many countries and regions. It expects all areas of the university to advance knowledge and learning at the highest level and to convey the products of its efforts to the world.