Dr. Brouwer directs an NIH-funded research program focused on hepatic drug disposition and development and refinement of in vitro model systems to predict in vivo hepatobiliary disposition, drug interactions, and hepatotoxicity. Ongoing nonclinical and clinical studies address the impact of altered hepatic transport (due to drug interactions, disease, and genetic factors) on systemic, hepatic, biliary and intestinal exposure to endogenous compounds, medications, and derived metabolites.
The full-time research technician will perform experiments utilizing in vitro techniques, human-derived tissue fractions, cell-based assays, and liquid chromatography – tandem mass spectrometry (LC-MS/MS) to study drug disposition, transport, and toxicity. The Research Technician will participate in experimental conduct, data collection, analysis, and interpretation; maintain cell cultures; maintain the MRP2-deficient TR- rat colony; perform western blots; order, organize, and store laboratory supplies; and assistant in training research students and other personnel in laboratory techniques and safety protocols.
Education and Experience:
Demonstrated possession of the competencies necessary to perform the work.
Must be able to read and understand the scientific literature and execute experiments as outlined in laboratory protocols. A high level of responsibility, independence, and good written and verbal communication skills are required. Proficiency with Microsoft Office (PowerPoint, Excel, Word) and strong math skills are required.
Bachelor's degree (B.S. or B.A.) in Chemistry, Biology, Biochemistry, Pharmacology or related discipline. 2-3 years of previous research experience in a biomedical or biological sciences laboratory. Research experience in drug transport and molecular biology is preferred.
The University of North Carolina at Chapel Hill is an equal opportunity and affirmative action employer. All qualified applicants will receive consideration for employment without regard to age, color, disability, gender, gender expression, gender identity, genetic information, race, national origin, religion, sex, sexual orientation, or status as a protected veteran.
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