This Picker Lab position at Vaccine & Gene Therapy Institute and Oregon National Primate Research Center reports directly to Dr. Yoshinori Fukazawa, and will have significant responsibility for supervising the activities of multiple simultaneous projects.
The primary goal of the Picker Laboratories is to use the Rhesus macaque (non-human primate, NHP) model to better understand the pathogenesis of HIV/AIDS, to develop and test therapies and vaccines, and to attempt to cure infected of their infection.
The Fukazawa scientific group, within the Picker Lab, is focused on investigating the nature of the HIV reservoir within an infected individual, and in testing ideas how to cure HIV on NHP models.
Under the supervision of Drs. Picker and Fukazawa, the technical staff of this group carries out the daily needs of ongoing experiments. Laboratory methods include cell isolation, tissue and virus culture, histology, and flow cytometry. Samples routinely include biohazards, especially Simian immunodeficiency virus (SIV: the NHP analogue of HIV).
The Research Associate will learn and master all of the laboratory tasks and operations, and will assume supervisory responsibilities associated with the multi-group coordination, logistics, and daily sample throughput. This position will have group leadership responsibilities, responsibility for training and supervising junior staff, and additional whole-lab duties, as assigned.
Representative work includes:
Early antiretroviral therapy limits SIV reservoir establishment to delay or prevent post-treatment viral rebound https://www.ncbi.nlm.nih.gov/pubmed/30082858
B cell follicle sanctuary permits persistent productive simian immunodeficiency virus infection in elite controllers https://www.ncbi.nlm.nih.gov/pubmed/25599132
Management of activities, staff effort, collaborator interactions, and reagent supplies for ongoing studies
Experimental tasks associated with AIDS vaccine and immunotherapy researches, including processing of Rhesus macaque tissue samples (many different types), in vitro virus infection, tissue cell culture, and staining test samples for flow cytometry.
Record-keeping, data analysis of FACS, immunological and virological assays, tabulation, graphing, abstraction, and reporting.
Additional responsibilities as assigned, supporting the operations of the larger laboratory community in Vaccine & Gene Therapy Institute.
Masters Degree or higher with major coursework in a related scientific discipline, or a Bachelors degree coupled with major courses in relevant science, and at least 5 years of relevant experience.
At least three years of laboratory experience.
Must be comfortable using computers (Mac, PC), supervising others, doing research with animals, and working with biohazardous samples.
Some immunology, tissue-processing, &/or flow cytometry background.
Some management experience.
Some experience with supervising, animal research, and biohazardous.
Willingness to work with pathogens potentially dangerous to humans
Willingness to work in Biosafety Level 2 and 3 facilities
Willingness and ability to work flexible hours
Physical demands & equipment usage:
Ability and willingness to work independently
Ability to carry and lift 35 lbs.
Ability to stand for three continuous hours a day
Ability to work on computer for five continuous hours a day
Able to perform the essential functions of the position with or without accommodation
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