This position is in the Department of Ophthalmology & Visual Sciences. This position is for the Medical School Campus.
The Williams Lab is seeking a postdoctoral researcher with experience in adaptive optics microscopy to study neuronal regeneration and preservation in retinal mouse models of injury and disease. This project will examine how retinal ganglion cells are effected by trauma and degenerative diseases at the subcellular level using in vivo imaging techniques. Responsibilities of the researcher will include but are not limited to: establishment of adaptive optics module to operate on existing 2-photon microscope for transpupillary imaging in mice; examining activity of genetically encoded biosensors localizes to organelles; imaging alterations in retinal axons, dendrites and glial processes in response to neurodegeneration; data collection and analysis; preparation of presentations and manuscripts.
The Williams lab is a research group at the Washington University School of Medicine. Our research goals are focused on identifying fundamental mechanisms of neuronal loss to better understand why neurons die or axons are damaged to ultimately establish new strategies for the preservation or restoration of neural tissue. We use multiple approaches, but focus on mouse models of retinal ganglion cell neurodegeneration, in vivo microscopy, AAV mediated gene delivery and knockout, along with transcriptomic and immunohistological analyses.
The postdoctoral researcher will have the opportunity to work with the broad Neuroscience community at the Washington University School of Medicine. Our lab has established collaborations with investigators specializing in electrophysiology, large volume electron microscopy and other areas to support independent research projects established by postdoctoral scholars. In addition to high-quality research facilities, career and professional development training for postdoctoral researchers is provided through the Office of Postdoctoral Affairs, Career Center, Teaching Center, and campus groups. Additional information on being a postdoc at Washington University in St. Louis can be found at postdoc.wustl.edu/prospective-postdocs.
PRIMARY DUTIES AND RESPONSIBILITIES:
Trains under the supervision of a faculty mentor, including (but not limited to):
Manages their own project, which should lead to a first author publication.
Develops expertise in isolation and transcriptomic analysis of retinal neurons, surgical approaches to optic nerve injury and glaucoma in mice, adeno associated virus production and application.
Develops proficiency in career skills, including writing, public speaking, networking, and critical evaluation of scientific literature.
Presents scientific work both inside and outside the University with excellent oral communication skills.
Assists with grant preparation and reporting.
Prepares and submits papers on research with excellent writing skills.
Designs research experiments.
Evaluates research findings and reports results.
Maintains conscientious discharge of his/her research responsibilities.
Maintains conformity with ethical standards in research.
Maintains compliance with good laboratory practice, including the maintenance of adequate research records.
Engages in open and timely discussion with their mentor regarding possession or distribution of material, reagents, or records belonging to their laboratory and any proposed disclosure of findings or techniques privately or in publications.
Maintains collegial conduct towards co-trainees, staff members and members of the research group.
Adheres to all applicable University policies, procedures and regulations. All data, research records and materials and other intellectual property generated in University laboratories remain the property of the University.
Recent Ph.D. graduate in neuroscience or a related field.
Experience in transcriptomic material generation and analysis, in vivo 2-photon microscopy, adeno-associated virus production and use, experimental design, and data analysis.
Demonstrated ability to implement laboratory procedures, conduct research and records findings.
Base pay is commensurate with experience.
Applicant Special Instructions:
Interested candidates should send a CV and cover letter to Dr. Phil Williams (firstname.lastname@example.org).
Washington University is an Equal Opportunity Employer. All qualified applicants will receive consideration for employment without regard to race, color, religion, age, sex, sexual orientation, gender identity or expression, national origin, genetic information, disability, or protected veteran status.
All external candidates receiving an offer for employment will be required to submit to pre-employment screening for this position. Current employees applying for a new position within the university may be subject to this requirement. The screenings will include a criminal background check and, as applicable for the position, other background checks, drug screen, employment and education or licensure/certification verification, physical examination, certain vaccinations and/or governmental registry checks. All offers are contingent upon successful completion of required screening.
Internal Applicant Instruction:
Please attach a copy of your most current signed performance evaluation (completed within the last 18 months) to your online account. If you have not received a performance evaluation, you may provide two current signed letters of recommendation (written within the last 18 months), preferably to include one letter from either a current or recent former supervisor. To attach these documents, go to: My Career Tools, Add Attachment, Attachment Type – Performance Reviews or Letters of Recommendation.
Washington University in St. Louis, a medium-sized, independent university, is dedicated to challenging its faculty and students alike to seek new knowledge and greater understanding of an ever-changing, multicultural world. The University offers more than 90 programs and almost 1,500 courses leading to bachelor's, master's and doctoral degrees in a broad spectrum of traditional and interdisciplinary fields, with additional opportunities for minor concentrations and individualized programs. The faculty is composed of scholars, scientists, artists and members of the learned professions. They serve society by teaching; by adding to the store of human art, creativity, understanding, and wisdom; and by providing direct services, such as health care.