The primary focus of the Seki Laboratory is to understand the role of innate immune and inflammatory signals in chronic liver diseases such as liver fibrosis, alcoholic and nonalcoholic steatohepatitis and hepatocellular carcinoma. In particular, our laboratory is interested in studying the interplay between hepatocytes and non-parenchymal cells (Kupffer cells and hepatic stellate cells) in chronic liver disease. Our research goal is to discover new mechanisms of and novel therapeutic targets for chronic liver disease.
Job Summary: The Division of Digestive & Liver Diseases at Cedars-Sinai Medical Center is looking for a Postdoctoral Scientist to join a hepatology research laboratory. The laboratory studies the molecular mechanisms of various liver diseases: alcoholic and non-alcoholic fatty liver disease, liver fibrosis, and liver cancer. Additionally, laboratory investigates the growth of metastatic liver tumors and the gut microbiome as it relates to nonalcoholic fatty liver disease.
Working independently but in close cooperation and in consultation with the principal investigator and other Research Scientists, as a Postdoctoral Scientist, you will conduct experiments in various ongoing projects. You will perform laboratory tasks that include, routine and complex laboratory procedures and experiments throughout the training period. You will develop, adapt, and implement new research techniques and protocols as well as analyze and interpret data. You may assist in preparation of grant proposals and will participate in publications and presentations as author or co-author. In this position, you will not responsible for generating grant funds.
Essential job duties and responsibilities:
May assist in preparation of grant proposals, but is not responsible for generating grant funds.
May participate in publications and presentations as author or co-author.
Designs and performs experiments. Will keep appropriate experimental records and documentation and analyze the results with the Principal Investigator.
Develops, adapts, and implements new research techniques and protocols.
Analyzes, interprets, summarizes and compiles data.
Performs routine and complex laboratory procedures and experiments throughout training period.
Operates and maintains laboratory equipment and instruments.
Operates standard office equipment.
Perform research activities involving live animals (mice).
Isolation of different hepatic cell populations and intracellular signaling of hepatic stellate cells, plasmacytoid dendritic cells, liver macrophages, and hepatocytes.
Will perform routine cellular, micro- and molecular biology procedures including, but not limited to Western blot, DNA/RNA/protein extraction, genotyping PCR, real time PCR, cell culture, transfection of plasmids, Immunohistochemistry, and staining.
Assist with the maintenance and perform genotyping by PCR of mouse colonies.
Participate and train in various surgical procedures and non-surgical procedures.
Providing healthcare for more than 100 years, Cedars-Sinai has evolved into one of the most dynamic and highly renowned medical centers in the world. Along with caring for patients, Cedars-Sinai is a hub for biomedical research and a training center for future physicians and other healthcare professionals. This attracts exceptional talent to Cedars-Sinai, including world-renowned physician-scientists who seek a place where they can both conduct research and see patients--the ideal formula for discovery and its translation into cures. Our patients benefit from access to doctors at the top of their fields, and our researchers have an ideal community in which to study the impact of healthcare challenges, and reflect that knowledge in their research. The greater Los Angeles area in which Cedars-Sinai resides possesses unparalleled cultural and ethnic diversity which offers outstanding opportunities for translational and clinical research and a dynamic environment for medical education.Although community based, Cedars-Sinai is a major t...eaching hospital affiliated with the David Geffen School of Medicine at the University of California, Los Angeles (UCLA). Cedars-Sinai has highly competitive graduate medical education programs in more than 50 specialty and subspecialty areas, a graduate program in biomedical sciences and translational medicine, a clinical scholars program directed towards junior physicians with aspirations to become clinical scientists, and post graduate training opportunities.There are more than 250 full-time faculty members at Cedars-Sinai. The voluntary medical staff, comprised of more than 2,200 specialty board-certified or board-qualified physicians, represent all of the specialties and subspecialties and collaborate with full-time medical staff in the teaching responsibilities of the graduate medical education programs.