Dana-Farber Cancer Institute (DFCI) and Deerfield Management have created the Center for Protein Degradation (CPD) at DFCI. The goals of the CPD are to create a next-generation protein degrader platform and interrogate and advance a large portfolio of protein degrader targets. This is an exceptional opportunity to join a newly founded research center that is pushing the boundaries of targeted protein degradation research and accelerating the translation of basic science into clinical solutions. Join our highly interactive team of scientists where we are creating new avenues of therapeutic intervention.
The Center for Protein Degradation (CPD) seeks a highly motivated individual to join the biology team as a SCIENTIST with a focus in studying the mechanisms of immune-mediated effects of targeted protein degraders. The individual will collaborate with mutliple research groups to identify biomarkers with an emphasis on the development and implementation of immunological assays to support pre-clinical and translational research. The individual will work closely with internal research teams, external collaborators, and contract research organizations (CROs) to design and develop strategies that establish proof-of-concept efficacy, identify clinically actionable pharmacodynamic measures of efficacy, and assess potential for adverse effects. The candidate will provide insights that impact the direction of our research, while also driving lab-based innovations. The individual will regularly present progress to the rest of the group and leadership.
Independently plan, manage, and perform biological experiments. Develop project proposals, timelines and resource needs, working closely with the Portfolio Manager and leadership. Monitor milestones and ensure deliverables are completed on time.
Collect and analyze experimental data and identify next steps based on outcomes.
Train research technicians and other scientific staff in methods/techniques.
Develop, implement, and deliver mechanistic insights into the mode of action of targeted degrader molecules.
Develop, perform, and analyze assays to assess immune endpoints (i.e. cytokine secretion, cell activation, proliferation, and cytotoxicity) and evaluate mechanisms of anti-tumor immunity.
Work closely with chemistry, biochemistry and proteomics teams to guide compound optimization and project progression.
Prepare presentations and present project status and outcomes at internal and external meetings.
Interact and liaise with internal experts, external experts, academic groups, and CROs to establish collaborations and projects.
Pursue opportunities to publish research externally.
Maintain clear and accurate records of experimental work (e.g., experimental methods, results/findings).
PhD degree in molecular/cellular biology, biochemistry, immunology or related disciplines.
Expertise in immunological assays, including FACS analysis and ELISAs.
Skilled in immune cell purification and phenotyping, and in performing immune endpoint analysis.
Demonstrated leadership in research projects related to drug development or translational applications.
Excellent communication and presentation skills.
Scientific drive, demonstrated by a proven track record of publications in peer reviewed journals.
Demonstrated ability to work in a fast-paced and dynamic environment.
Ability to work independently as well as in a collaborative and team environment.
Proficiency in all common Microsoft Office and GraphPad Prism software.
Excellent organizational and prioritization skills. Strong attention to detail.
2 years of relevant postdoctoral experience, preferably in an industrial setting.
Strong background in immunology is highly preferred.
Experience in cellular and in vivo tumor models.
Experience in running multi-faceted projects is preferred.
Experience managing more junior staff is desirable.
Dana-Farber Cancer Institute is an equal opportunity employer and affirms the right of every qualified applicant to receive consideration for employment without regard to race, color, religion, sex, gender identity or expression, national origin, sexual orientation, genetic information, disability, age, ancestry, military service, protected veteran status, or other groups as protected by law.
Internal Number: 2020-20706
About Dana-Farber Cancer Institute
Located in Boston and the surrounding communities, Dana-Farber Cancer Institute brings together world renowned clinicians, innovative researchers and dedicated professionals, allies in the common mission of conquering cancer, HIV/AIDS and related diseases. Combining extremely talented people with the best technologies in a genuinely positive environment, we provide compassionate and comprehensive care to patients of all ages; we conduct research that advances treatment; we educate tomorrow's physician/researchers; we reach out to under-served members of our community; and we work with amazing partners, including other Harvard Medical School-affiliated hospitals.